Suppr超能文献

边缘性减压病事件:与减压和减压病模型中的应用的关系。

Marginal DCS events: their relation to decompression and use in DCS models.

机构信息

Mechanical Engineering Dept., Duke Univ., Durham, NC 27708-0300, USA.

出版信息

J Appl Physiol (1985). 2009 Nov;107(5):1539-47. doi: 10.1152/japplphysiol.00185.2009. Epub 2009 Aug 20.

Abstract

We consider the nature and utility of marginal decompression sickness (DCS) events in fitting probabilistic decompression models to experimental dive trial data. Previous works have assigned various fractional weights to marginal DCS events, so that they contributed to probabilistic model parameter optimization, but less so than did full DCS events. Inclusion of fractional weight for marginal DCS events resulted in more conservative model predictions. We explore whether marginal DCS events are correlated with exposure to decompression or are randomly occurring events. Three null models are developed and compared with a known decompression model that is tuned on dive trial data containing only marginal DCS and non-DCS events. We further investigate the technique by which marginal DCS events were previously included in parameter optimization, explore the effects of fractional weighting of marginal DCS events on model optimization, and explore the rigor of combining data containing full and marginal DCS events for probabilistic DCS model optimization. We find that although marginal DCS events are related to exposure to decompression, empirical dive data containing marginal and full DCS events cannot be combined under a single DCS model. Furthermore, we find analytically that the optimal weight for a marginal DCS event is 0. Thus marginal DCS should be counted as no-DCS events when probabilistic DCS models are optimized with binomial likelihood functions. Specifically, our study finds that inclusion of marginal DCS events in model optimization to make the dive profiles more conservative is counterproductive and worsens the model's fit to the full DCS data.

摘要

我们考虑了边缘减压病 (DCS) 事件的性质和用途,以便将概率减压模型拟合到实验潜水试验数据中。以前的工作为边缘 DCS 事件分配了各种分数权重,以便它们有助于概率模型参数优化,但不如完整 DCS 事件重要。包含边缘 DCS 事件的分数权重会导致模型预测更加保守。我们探讨了边缘 DCS 事件是否与减压暴露有关,或者是否是随机发生的事件。我们开发了三个零假设模型,并将其与已知的减压模型进行了比较,该模型是根据仅包含边缘 DCS 和非 DCS 事件的潜水试验数据进行调整的。我们进一步研究了以前在参数优化中包含边缘 DCS 事件的技术,探讨了边缘 DCS 事件分数权重对模型优化的影响,并探讨了将包含完整和边缘 DCS 事件的数据结合起来进行概率 DCS 模型优化的严格性。我们发现,尽管边缘 DCS 事件与减压暴露有关,但在单个 DCS 模型下,包含边缘和完整 DCS 事件的经验潜水数据无法结合。此外,我们从分析上发现,边缘 DCS 事件的最佳权重为 0。因此,在使用二项式似然函数优化概率 DCS 模型时,应将边缘 DCS 视为无 DCS 事件。具体来说,我们的研究发现,将边缘 DCS 事件纳入模型优化以使潜水剖面更加保守是适得其反的,会使模型对完整 DCS 数据的拟合效果变差。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验