Morinaga Hisayo, Ohta Takeshi, Matsui Kenichi, Sasase Tomohiko, Fukuda Sumiaki, Ito Makoto, Ueda Masatoshi, Ishii Yukihito, Miyajima Katsuhiro, Matsushita Mutsuyoshi
Japan Tobacco Inc., Central Pharmaceutical Research Institute, 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.
Exp Diabetes Res. 2009;2009:715057. doi: 10.1155/2009/715057. Epub 2009 Aug 19.
Spontaneously Diabetic Torii-fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.
自发性糖尿病Torii-fa/fa（SDT肥胖）大鼠是一种肥胖型2型糖尿病的新模型。SDT肥胖大鼠表现出与食欲亢进相关的肥胖。在本研究中，SDT肥胖大鼠在6至22周龄时与SDT-+/+（SDT）大鼠进行配对喂养。配对喂养大鼠在12周龄时内脏脂肪重量与皮下脂肪重量之比（V/S）降低。附睾和腹膜后脂肪等腹腔内脂肪重量减少，而肠系膜脂肪重量无变化。配对喂养大鼠附睾脂肪的细胞大小有减小趋势。12周龄配对喂养大鼠附睾脂肪中的葡萄糖氧化水平恢复到与SDT大鼠相似的水平。这些结果表明，SDT肥胖大鼠是评估脂肪组织功能或形态特征以及开发新型抗肥胖药物的有用模型。
