Xu Jin, Yang Yi, Sun Jiae, Ding Yunzhen, Su Liyun, Fang Zhaoyin, Glass Roger I
Pediatric Institute, Children's Hospital, Fudan University, Shanghai 200032, China.
J Clin Virol. 2009 Jan;44(1):58-61. doi: 10.1016/j.jcv.2008.09.012. Epub 2008 Nov 17.
Rotavirus is the most common cause of severe diarrhea in children in the world. Knowing the prevalence and genotypes of these infections is important for implementing vaccination programs.
To determine the prevalence and genotypes of rotavirus infections in Shanghai, China between 2001 and 2005.
Stool specimens were analyzed from children under 5 years old who were hospitalized for acute gastroenteritis.
Of 5411 specimens, 1436 (26.5%) were rotavirus-positive. More than 80% of children with rotavirus infections were younger than 2 years old. Prevalence peaked from October to December each year. The G3, P[8], and P[8]G3 genotypes were the most common during these 5 years. The prevalence of the G1 genotype decreased from 29% in 2001 to 2% in 2004.
In Shanghai, use of currently available vaccines against rotaviruses would be effective, especially for infants less than 2 years old. Information on the variations of circulating genotypes in this area of China provides useful data for formulating vaccine policy and evaluating vaccine efficacy.
轮状病毒是全球儿童严重腹泻的最常见病因。了解这些感染的流行情况和基因型对于实施疫苗接种计划至关重要。
确定2001年至2005年期间中国上海轮状病毒感染的流行情况和基因型。
对因急性胃肠炎住院的5岁以下儿童的粪便标本进行分析。
在5411份标本中，1436份（26.5%）轮状病毒呈阳性。超过80%的轮状病毒感染儿童年龄小于2岁。每年10月至12月发病率达到高峰。在这5年中，G3、P[8]和P[8]G3基因型最为常见。G1基因型的流行率从2001年的29%降至2004年的2%。
在上海，使用目前可用的轮状病毒疫苗将是有效的，特别是对于2岁以下的婴儿。中国该地区流行基因型变异的信息为制定疫苗政策和评估疫苗效果提供了有用的数据。
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