生物材料设计策略治疗脊髓损伤。
Biomaterial design strategies for the treatment of spinal cord injuries.
机构信息
Chemical Engineering Department, Stanford University, Stanford, California 4305-4045, USA.
出版信息
J Neurotrauma. 2010 Jan;27(1):1-19. doi: 10.1089/neu.2009.0948.
Abstract
The highly debilitating nature of spinal cord injuries has provided much inspiration for the design of novel biomaterials that can stimulate cellular regeneration and functional recovery. Many experts agree that the greatest hope for treatment of spinal cord injuries will involve a combinatorial approach that integrates biomaterial scaffolds, cell transplantation, and molecule delivery. This manuscript presents a comprehensive review of biomaterial-scaffold design strategies currently being applied to the development of nerve guidance channels and hydrogels that more effectively stimulate spinal cord tissue regeneration. To enhance the regenerative capacity of these two scaffold types, researchers are focusing on optimizing the mechanical properties, cell-adhesivity, biodegradability, electrical activity, and topography of synthetic and natural materials, and are developing mechanisms to use these scaffolds to deliver cells and biomolecules. Developing scaffolds that address several of these key design parameters will lead to more successful therapies for the regeneration of spinal cord tissue.
摘要
脊髓损伤的高度致残性为新型生物材料的设计提供了很多灵感，这些生物材料可以刺激细胞再生和功能恢复。许多专家认为，治疗脊髓损伤的最大希望将涉及一种组合方法，即将生物材料支架、细胞移植和分子递送来整合在一起。本文全面综述了目前应用于神经引导通道和水凝胶开发的生物材料支架设计策略，这些策略可以更有效地刺激脊髓组织再生。为了提高这两种支架类型的再生能力，研究人员专注于优化合成和天然材料的机械性能、细胞黏附性、生物降解性、电活性和形貌，并正在开发利用这些支架输送细胞和生物分子的机制。开发能够解决这些关键设计参数的支架，将为脊髓组织再生的治疗带来更大的成功。
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