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脊髓再生的新策略。

Novel Strategies for Spinal Cord Regeneration.

机构信息

"Gr. T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

"Prof. Dr. N. Oblu" Emergency Clinical Hospital, 700309 Iasi, Romania.

出版信息

Int J Mol Sci. 2022 Apr 20;23(9):4552. doi: 10.3390/ijms23094552.

DOI:10.3390/ijms23094552
PMID:35562941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9102050/
Abstract

A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.

摘要

脊髓损伤 (SCI) 是最具破坏性的损伤之一，因为它会破坏中枢神经系统的连续性和传导性，导致复杂的病理生理学。受纳米技术、干细胞生物学和材料科学进步的鼓舞，研究人员提出了各种用于脊髓再生的跨学科方法。在这方面，本综述旨在探讨 SCI 治疗和脊髓修复的最新进展。具体来说，它简要描述了 SCI 的特征，然后广泛讨论了用于脊髓递药的新型纳米载体（例如，基于金属的、基于聚合物的、脂质体）、用于 SCI 治疗的相关生物分子（例如，生长因子、外泌体）、创新的细胞疗法以及用于脊髓再生的新型天然和合成生物材料支架。

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