Wang Zhao, Chen Xi, Wu Lin, Tian Li-Ping, Wang Jing-Shi
Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Aug;17(4):1064-6.
The study was aimed to explore the diagnostic significance of hemophagocytosis in the patients with hemophagocytic lymphohistiocytosis (HLH). 61 suspected HLH patients from June 2005 to October 2008 were enrolled in the study. The suspected HLH patients were divided into confirmed group (43 out of 61) and excluded group (18 out of 61) according to HLH-2004 diagnostic criteria. The incidences of hemophagocytosis in bone marrow, spleen or lymph nodes were compared in all groups. The results indicated that the hemophagocytosis in bone marrow, spleen or lymph nodes was found in 33 patients of confirmed group, while the hemophagocytosis was found in 4 patients of excluded group. The sensitivity of hemophagocytosis for the diagnosis of HLH was 76.7%, and its specificity was 77.8%. In conclusion, hemophagocytosis is a helpful marker for the diagnosis of most but not all HLH patients, however, the lack of hemophagocytosis does not mean to exclude the diagnosis of HLH.
本研究旨在探讨噬血细胞现象在噬血细胞性淋巴组织细胞增生症（HLH）患者中的诊断意义。选取了2005年6月至2008年10月期间61例疑似HLH患者纳入研究。根据HLH - 2004诊断标准，将疑似HLH患者分为确诊组（61例中的43例）和排除组（61例中的18例）。比较了所有组中骨髓、脾脏或淋巴结中噬血细胞现象的发生率。结果显示，确诊组33例患者存在骨髓、脾脏或淋巴结中的噬血细胞现象，而排除组4例患者存在噬血细胞现象。噬血细胞现象对HLH诊断的敏感性为76.7%，特异性为77.8%。总之，噬血细胞现象是大多数但并非所有HLH患者诊断的有用标志物，然而，缺乏噬血细胞现象并不意味着排除HLH的诊断。
