Aryal Madan Raj, Badal Madan, Giri Smith, Aryal Shambhu
Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania, USA.
BMJ Case Rep. 2013 Jun 27;2013:bcr2013009651. doi: 10.1136/bcr-2013-009651.
Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disorder resulting from a highly stimulated immune response with uncontrolled accumulation of lymphocytes and macrophages in multiple organs. Both the inherited and acquired forms of this disease exist; the latter can sometimes occur secondary to different malignancies. In this report, we present a middle-aged Hispanic man who presented with features of septic shock during the course of chemotherapy for squamous cell carcinoma of the neck. Despite aggressive treatment for septic shock, he rapidly deteriorated and died after 30 h of admission. Autopsy findings confirmed a diagnosis of HLH. HLH should be recognised as a serious adverse event during chemotherapy for different malignancies including squamous cell carcinoma of the neck.
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见但可能致命的疾病，由高度刺激的免疫反应导致淋巴细胞和巨噬细胞在多个器官中不受控制地积聚引起。这种疾病有遗传和后天获得两种形式；后者有时继发于不同的恶性肿瘤。在本报告中，我们介绍了一名中年西班牙裔男性，他在颈部鳞状细胞癌化疗过程中出现感染性休克的症状。尽管对感染性休克进行了积极治疗，但他在入院30小时后迅速恶化并死亡。尸检结果证实诊断为HLH。HLH应被视为包括颈部鳞状细胞癌在内的不同恶性肿瘤化疗期间的严重不良事件。
