一名肝移植患者发生耐甲氧西林金黄色葡萄球菌腹膜炎和菌血症时，使用普通万古霉素可能出现治疗失败。
Potential therapeutic failure of generic vancomycin in a liver transplant patient with MRSA peritonitis and bacteremia.
作者信息
Rodriguez Carlos A, Agudelo Maria, Cataño Juan C, Zuluaga Andres F, Vesga Omar
机构信息
GRIPE: Grupo Investigador de Problemas en Enfermedades Infecciosas, University of Antioquia Medical School, Medellín, Colombia.
出版信息
J Infect. 2009 Oct;59(4):277-80. doi: 10.1016/j.jinf.2009.08.005. Epub 2009 Aug 19.
PMID:19698745
Abstract
We report a case of generic vancomycin treatment failure in a liver transplant patient with MRSA peritonitis and bacteremia, followed by a rapid sterilization of blood and peritoneal fluid after switching to the branded product. It raises concern about therapeutic equivalence of generic vancomycin.
摘要
我们报告了一例肝移植患者发生耐甲氧西林金黄色葡萄球菌腹膜炎和菌血症，使用普通万古霉素治疗失败，而改用品牌产品后血液和腹腔液迅速除菌的病例。这引发了对普通万古霉素治疗等效性的关注。
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