Sharma Deepali, Patel Rahul P, Zaidi Syed Tabish R, Sarker Md Moklesur Rahman, Lean Qi Ying, Ming Long C
Pharmacy, School of Medicine, University of Tasmania, HobartTAS, Australia.
Department of Pharmacy, State University of BangladeshDhaka, Bangladesh.
Front Pharmacol. 2017 Aug 21;8:546. doi: 10.3389/fphar.2017.00546. eCollection 2017.
Ciprofloxacin, a second generation broad spectrum fluoroquinolone, is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin has a high oral bioavailability and a large volume of distribution. It is used for the treatment of a wide range of infections including urinary tract infections caused by susceptible bacteria. However, the availability and use of substandard and spurious quality of oral ciprofloxacin formulations in the developing countries has been thought to have contributed toward increased risk of treatment failure and bacterial resistance. Therefore, quality control and bioequivalence studies of the commercially available oral ciprofloxacin formulations should be monitored. Appropriate actions should be taken against offending manufacturers in order to prevent the sale of substandard and spurious quality of ciprofloxacin formulations.
环丙沙星是第二代广谱氟喹诺酮类药物，对革兰氏阳性菌和革兰氏阴性菌均有活性。环丙沙星口服生物利用度高，分布容积大。它用于治疗多种感染，包括由易感细菌引起的尿路感染。然而，发展中国家口服环丙沙星制剂存在质量不合格和假冒伪劣的情况，这被认为增加了治疗失败和细菌耐药的风险。因此，应对市售口服环丙沙星制剂进行质量控制和生物等效性研究监测。应对违规制造商采取适当行动，以防止销售质量不合格和假冒伪劣的环丙沙星制剂。
