Rubio-Somoza Ignacio, Cuperus Joshua T, Weigel Detlef, Carrington James C
Department of Molecular Biology, Max Planck Institute for Developmental Biology, D-72076 Tuebingen, Germany.
Curr Opin Plant Biol. 2009 Oct;12(5):622-7. doi: 10.1016/j.pbi.2009.07.003. Epub 2009 Aug 19.
The expansion of gene families for miRNA and tasiRNA, small RNA effector proteins (ARGONAUTEs or AGOs), and miRNA/tasiRNA targets has contributed to regulatory diversity in plants. Loss or acquisition of small RNA-generating loci and target site sequences in multigene families represent striking examples of subfunctionalization or neo-functionalization, where regulatory diversity is achieved at the post-transcriptional level. Differential regulation of small RNA and target gene family members, and evolution of unique functionality of distinct small RNA-AGO complexes, provide further regulatory diversity. Here, we focus on the idea of distinct small RNA-target transcript pairs as nodes within biological networks, and review progress toward understanding the role of small RNA-target nodes in the context of auxin signaling.
微小RNA（miRNA）和反式作用小干扰RNA（tasiRNA）、小RNA效应蛋白（AGO蛋白）以及miRNA/tasiRNA靶标的基因家族扩张，促成了植物中的调控多样性。多基因家族中产生小RNA的基因座和靶位点序列的丢失或获得，是亚功能化或新功能化的显著例子，其中调控多样性是在转录后水平实现的。小RNA和靶基因家族成员的差异调控，以及不同小RNA-AGO复合体独特功能的进化，提供了进一步的调控多样性。在这里，我们聚焦于不同的小RNA-靶转录本对作为生物网络节点的观点，并综述在生长素信号传导背景下理解小RNA-靶标节点作用方面的进展。
