Srinivasan Sathanur R, Wang Ren, Chen Wei, Wei Christine Y, Xu Jihua, Berenson Gerald S
Tulane Center for Cardiovascular Health, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
Am J Cardiol. 2009 Sep 1;104(5):721-4. doi: 10.1016/j.amjcard.2009.04.037. Epub 2009 Jun 24.
Data on the utility of the waist-to-height ratio in detecting central obesity and related cardiovascular risk among normal weight younger adults are scant. This aspect was examined in 639 normal weight (body mass index 18.5 to 24.9 kg/m(2)) black and white adults (75% white and 36% men) 20 to 44 years old. The subjects with a waist-to-height ratio > or =0.5 were grouped as having central obesity normal weight, with the rest considered the control group. The subjects with central obesity, compared to the controls, after adjusting for age, race, and gender, had significantly greater diastolic blood pressure, mean arterial pressure, low-density lipoprotein cholesterol level, triglycerides, triglycerides/high-density lipoprotein cholesterol ratio, insulin, homeostasis model assessment of insulin resistance, uric acid, C-reactive protein, and liver function enzymes (alanine aminotransferase and gamma-glutamyl transferase). On multivariate analysis, the central obesity group compared to the control group was 1.9, 2.2, 2.9, and 2.5 times more likely to have significantly adverse levels (top tertile vs the rest) of mean arterial pressure, triglycerides/high-density lipoprotein cholesterol ratio, homeostasis model assessment of insulin resistance, and C-reactive protein, respectively. The central obesity group also had a greater prevalence of dyslipidemia, hypertension, insulin resistance, hyperuricemia, and elevated C-reactive protein. The age-, race-, and gender-adjusted mean value of the common carotid intima-media thickness, a measure of subclinical atherosclerosis, was greater in the central obesity group compared to the control group (0.76 vs 0.71 mm, p = 0.009). In conclusion, these findings underscore the utility of the waist-to-height ratio in detecting central obesity and related adverse cardiovascular risk among normal weight younger adults.
关于腰高比在检测正常体重的年轻成年人中心性肥胖及相关心血管风险方面效用的数据很少。在639名年龄在20至44岁之间的正常体重（体重指数为18.5至24.9kg/m²）的黑人和白人成年人（75%为白人，36%为男性）中对这一方面进行了研究。腰高比≥0.5的受试者被归为中心性肥胖正常体重组，其余的被视为对照组。在调整年龄、种族和性别后，与对照组相比，中心性肥胖的受试者舒张压、平均动脉压、低密度脂蛋白胆固醇水平、甘油三酯、甘油三酯/高密度脂蛋白胆固醇比值、胰岛素、胰岛素抵抗的稳态模型评估、尿酸、C反应蛋白和肝功能酶（丙氨酸转氨酶和γ-谷氨酰转移酶）显著更高。在多变量分析中，与对照组相比，中心性肥胖组平均动脉压、甘油三酯/高密度脂蛋白胆固醇比值、胰岛素抵抗的稳态模型评估和C反应蛋白出现显著不良水平（最高三分位数与其余部分相比）的可能性分别高出1.9倍、2.2倍、2.9倍和2.5倍。中心性肥胖组血脂异常、高血压、胰岛素抵抗、高尿酸血症和C反应蛋白升高的患病率也更高。作为亚临床动脉粥样硬化指标的颈总动脉内膜中层厚度的年龄、种族和性别调整后平均值，中心性肥胖组高于对照组（0.76对vs0.71mm；p = 0.009）。总之，这些发现强调了腰高比在检测正常体重年轻成年人中心性肥胖及相关不良心血管风险方面的效用。
