Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Center for Critical Care, The Ohio State University Medical Center, Columbus, OH 43210, USA.
Clin Chest Med. 2009 Sep;30(3):495-508, viii. doi: 10.1016/j.ccm.2009.05.008.
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for ICU admission and mechanical ventilation. ALI/ARDS also consumes significant health care resources and is a common cause of death in ICU patients. Obesity produces changes in respiratory system physiology that could affect outcomes for ALI/ARDS patients and their response to treatment. Additionally, the biochemical alterations seen in obese patients, such as increased inflammation and altered metabolism, could affect the risk of developing ALI/ARDS in patients with another risk factor (eg, sepsis). The few studies that have examined the influence of obesity on the outcomes from ALI/ARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care.
急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）是 ICU 收治和机械通气的常见指征。ALI/ARDS 还消耗大量医疗资源，是 ICU 患者死亡的常见原因。肥胖会改变呼吸系统的生理机能，从而影响 ALI/ARDS 患者的预后及其对治疗的反应。此外，肥胖患者的生化改变，如炎症增加和代谢改变，可能会影响有其他危险因素（如脓毒症）的患者发生 ALI/ARDS 的风险。少数研究检查了肥胖对 ALI/ARDS 结局的影响，但结果并不一致。此外，观察到的结果可能因提供的护理差异而存在偏差。
