Dong Li, Chen Chengshui, Yang Qi, Zheng Yanwen, Feng Xueren, Chen Fang, Huang Gang, Dai Yuanrong, Pan Zhijie, Ge Huiqing, Zhao Tian, Qin Guangyue, Li Zhijun
The First Affiliated Hospital of Wenzhou Medical University, Department of Respiratory and Critical Care Medicine, Shangcai Village, Nanbaixiang Street, Ouhai District, Wenzhou, Zhejiang Province 325006, China.
The First People's Hospital in Jiaxing, Respiratory Department, 1882 Zhonghuan Nan Road, Nanhu District, Jiaxing, Zhejiang Province 314000, China.
J Trop Med. 2022 Mar 26;2022:5500899. doi: 10.1155/2022/5500899. eCollection 2022.
Accurate interpretation of lung function tests requires appropriate spirometry reference values derived from large-scale population-specific epidemiological surveys. The aim of this cross-sectional study was to establish normal spirometric values for the population of healthy, nonsmoking Han Chinese adults residing in Zhejiang province, China.
We measured lung function parameters such as forced expiratory volume in 1 s, forced vital capacity, peak expiratory flow, maximal midexpiratory flow, and diffusion capacity for carbon monoxide and considered age, height, and weight as independent factors that may modify these parameters. The clinical data were divided into the study arm and validation group. The study arms were used to construct predictive equations using stepwise multiple linear regression, and data from the validation group were used to assess the robustness of the equations.
The 3866 participants were randomized into a study arm ( = 1,949) and a validation arm ( = 1,917). Lung function parameters had a negative association with age and a positive association with height. Data from the two groups were similar. Predictive equations were constructed from the study arm, and the validation group was used to test the feasibility of the reference equations.
The reference values we derived can be used to evaluate lung function in this cohort in both epidemiological studies and clinical practice.
准确解读肺功能测试需要从大规模特定人群的流行病学调查中得出合适的肺量计参考值。这项横断面研究的目的是为居住在中国浙江省的健康、不吸烟的汉族成年人群建立正常的肺量计值。
我们测量了诸如1秒用力呼气量、用力肺活量、呼气峰值流速、最大呼气中期流速和一氧化碳弥散量等肺功能参数，并将年龄、身高和体重视为可能影响这些参数的独立因素。临床数据分为研究组和验证组。研究组用于通过逐步多元线性回归构建预测方程，验证组的数据用于评估方程的稳健性。
3866名参与者被随机分为研究组（n = 1949）和验证组（n = 1917）。肺功能参数与年龄呈负相关，与身高呈正相关。两组数据相似。从研究组构建预测方程，并用验证组测试参考方程的可行性。
我们得出的参考值可用于在流行病学研究和临床实践中评估该队列人群的肺功能。
