万古霉素从磷酸钙-硫酸钙微球中的体外洗脱特性。
The in vitro elution characteristics of vancomycin from calcium phosphate-calcium sulfate beads.
作者信息
Scharer Brandon M, Sanicola Shawn M
机构信息
Wheaton Franciscan Healthcare, Milwaukee, WI 53222, USA.
出版信息
J Foot Ankle Surg. 2009 Sep-Oct;48(5):540-2. doi: 10.1053/j.jfas.2009.05.001. Epub 2009 Jun 30.
UNLABELLED
The purpose of this study was to determine the elution characteristics of vancomycin when combined with a calcium phosphate-calcium sulfate mixture to form antibiotic beads in an in vitro environment. The beads were placed in phosphate-buffered saline and kept at 36 degrees C for 6 weeks. Three separate assays were undertaken, after which the phosphate-buffered saline was assayed at 24-hour intervals. Elution of the antibiotic was sustained at a gradual rate for 22 days. The amount of vancomycin assayed nearly equaled the calculated amount of antibiotic per bead measured during bead construction. In conclusion, calcium phosphate-calcium sulfate composite beads, when combined with vancomycin, elute vancomycin in a gradual and sustained fashion for 22 days in vitro.
LEVEL OF CLINICAL EVIDENCE
未标注
本研究的目的是在体外环境中确定万古霉素与磷酸钙 - 硫酸钙混合物结合形成抗生素珠时的洗脱特性。将珠子置于磷酸盐缓冲盐溶液中，并在36℃下保存6周。进行了三项独立的测定，之后每隔24小时对磷酸盐缓冲盐溶液进行测定。抗生素的洗脱以逐渐的速率持续了22天。测定的万古霉素量几乎等于在珠子制备过程中测量的每颗珠子计算的抗生素量。总之，磷酸钙 - 硫酸钙复合珠与万古霉素结合时，在体外以逐渐且持续的方式洗脱万古霉素达22天。
临床证据水平
2级。
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