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德国西北部提交进行呼吸道诊断的接种和未接种疫苗猪中猪繁殖与呼吸综合征活疫苗病毒(欧洲和北美基因型)的频率

Frequency of PRRS live vaccine virus (European and North American genotype) in vaccinated and non-vaccinated pigs submitted for respiratory tract diagnostics in North-Western Germany.

作者信息

grosse Beilage Elisabeth, Nathues Heiko, Meemken Diana, Harder Timm C, Doherr Marcus G, Grotha Inga, Greiser-Wilke Irene

机构信息

Field Station for Epidemiology, University of Veterinary Medicine Hannover, Buescheler Str. 9, D-49456 Bakum, Germany.

出版信息

Prev Vet Med. 2009 Nov 1;92(1-2):31-7. doi: 10.1016/j.prevetmed.2009.07.010. Epub 2009 Aug 22.

Abstract

The frequency of PRRSV corresponding to live vaccines and wild-type was determined in 902 pigs from North-Western Germany submitted for post-mortem examination. Overall, 18.5% of the samples were positive for the EU wild-type virus. EU genotype vaccine virus was detected in 1.3% and the NA genotype vaccine virus in 8.9% of all samples. The detection of the EU vaccine was significantly higher in pigs vaccinated with the corresponding vaccine (OR=9.4). Pigs vaccinated with NA genotype had significantly higher detection chances for the corresponding vaccine virus when compared to non-vaccinated animals (OR=3.34) animals, however, NA vaccine was also frequently detected in non-vaccinated pigs. Concluding, the dynamics of NA genotype vaccine and EU wild-type virus corresponds with studies on PRRSV spread in endemically infected herds. The potential of spontaneous spread of the NA genotype vaccine should be considered in the planning of eradication programs.

摘要

在德国西北部接受尸检的902头猪中,测定了与活疫苗和野生型相对应的猪繁殖与呼吸综合征病毒(PRRSV)的频率。总体而言,18.5%的样本对欧盟野生型病毒呈阳性。在所有样本中,1.3%检测到欧盟基因型疫苗病毒,8.9%检测到北美基因型疫苗病毒。在接种相应疫苗的猪中,欧盟疫苗的检测率显著更高(比值比=9.4)。与未接种疫苗的动物相比,接种北美基因型疫苗的猪检测到相应疫苗病毒的几率显著更高(比值比=3.34),然而,在未接种疫苗的猪中也经常检测到北美疫苗。总之,北美基因型疫苗和欧盟野生型病毒的动态与PRRSV在地方流行感染猪群中传播的研究结果相符。在根除计划的规划中应考虑北美基因型疫苗自发传播的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/383d/7114236/3d842dff1b75/gr1.jpg

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