Kiss I, Sámi L, Kecskeméti S, Hanada K
Central Veterinary Institute, Institute of Debrecen, Debrecen, Hungary.
Arch Virol. 2006 Nov;151(11):2269-76. doi: 10.1007/s00705-006-0805-0. Epub 2006 Jun 9.
Recurrence of porcine respiratory and reproductive syndrome (PRRS) was observed on a pig farm after introducing two PRRS live virus vaccines to combat preceding outbreaks. The phylogenetic analysis of the nucleotide sequence encoding the GP5 envelope glycoprotein and the nucleocapsid protein coding sequences (ORF5 and ORF7, respectively) showed a close genetic relationship between the new outbreak-related and one of the vaccine viruses, while the prevailing PRRS virus genetic variants disappeared from the farm. These findings, supported by the epidemiological data, indicate that the new variant PRRS viruses might originate from a vaccine virus and demonstrate the limited efficacy of modified live vaccines against heterologous PRRS virus strains.
在引入两种猪繁殖与呼吸综合征（PRRS）活病毒疫苗以应对先前疫情后，一个养猪场出现了PRRS复发情况。对编码GP5包膜糖蛋白的核苷酸序列和核衣壳蛋白编码序列（分别为开放阅读框5和开放阅读框7）进行系统发育分析表明，新的疫情相关病毒与其中一种疫苗病毒存在密切的遗传关系，而当时流行的PRRS病毒基因变体在该养殖场消失了。这些发现得到了流行病学数据的支持，表明新的变异PRRS病毒可能源自一种疫苗病毒，并证明了改良活疫苗对异源PRRS病毒株的疗效有限。
