2008 年阿根廷风疹疫情病毒的系统进化分析。
Phylogenetic analysis of rubella viruses isolated in 2008 outbreak in Argentina.
机构信息
Laboratorio de Virología, Hospital de Niños R. Gutiérrez, Buenos Aires, Argentina.
出版信息
J Clin Virol. 2009 Nov;46(3):286-9. doi: 10.1016/j.jcv.2009.07.018. Epub 2009 Aug 22.
BACKGROUND
A rubella outbreak was recorded in Buenos Aires during 2008.
OBJECTIVES
The objective of this communication is to present the genetic and phylogenetic analyses of wild-type RUBV circulating in Buenos Aires during the 2008 outbreak.
STUDY DESIGN
Throat swab samples collected from patients diagnosed with rubella between June 2008 and December 2008 were inoculated in cell culture and 23 isolates were sequenced.
RESULTS
Phylogenetic analysis of the WHO-recommended window (nt 8731-9469) of the E1 envelope glycoprotein was performed and all isolates clustered with the 2B genotype.
CONCLUSIONS
Genotype 2B seems to be endemically circulating in the Southern cone of Latin America, thus causing recent outbreaks.
背景
2008 年布宜诺斯艾利斯发生风疹疫情。
目的
本报告旨在分析 2008 年布宜诺斯艾利斯风疹野病毒的遗传进化特征。
研究设计
2008 年 6 月至 12 月期间，采集经临床诊断的风疹患者咽拭子标本接种细胞培养，对 23 株病毒进行了测序。
结果
对 E1 包膜糖蛋白（nt8731-9469）进行了 WHO 推荐的基因片段分析，所有分离株均与基因型 2B 聚为一簇。
结论
基因型 2B 似乎在拉丁美洲南部呈地方性流行，导致了近期的暴发。
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