高密度脂蛋白代谢与人类胚胎。

High-density lipoprotein metabolism and the human embryo.

机构信息

Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, CA 94115-0916, USA.

出版信息

Hum Reprod Update. 2010 Jan-Feb;16(1):20-38. doi: 10.1093/humupd/dmp029.

DOI:10.1093/humupd/dmp029

PMID:19700490

Abstract

BACKGROUND

High-density lipoprotein (HDL) appears to be the dominant lipoprotein particle in human follicular fluid (FF). The reported anti-atherogenic properties of HDL have been attributed in part to reverse cholesterol transport. The discoveries of the scavenger receptor class B type I (SR-BI) and the ATP-binding cassette A1 lipid (ABCA1) transporter have generated studies aimed at unraveling the pathways of HDL biogenesis, remodeling and catabolism. The production of SR-BI and ABCA1 knockout mice as well as other lipoprotein metabolism-associated mutants has resulted in reduced or absent fertility, leading us to postulate the existence of a human hepatic-ovarian HDL-associated axis of fertility. Here, we review an evolving literature on the role of HDL metabolism on mammalian fertility and oocyte development.

METHODS

An extensive online search was conducted of published articles relevant to the section topics discussed. All relevant English language articles contained in Pubmed/Medline, with no specific time frame for publication, were considered for this narrative review. Cardiovascular literature was highly cited due to the wealth of relevant knowledge on HDL metabolism, and the dearth thereof in the reproductive field.

RESULTS

Various vertebrate models demonstrate a role for HDL in embryo development and fertility. In our clinical studies, FF levels of HDL cholesterol and apolipoprotein AI levels were negatively associated with embryo fragmentation, but not with embryo cell cleavage rate. However, the HDL component, paraoxonase 1 arylesterase activity, was positively associated with embryo cell cleavage rate.

CONCLUSIONS

HDL contributes to intra-follicular cholesterol homeostasis which appears to be important for successful oocyte and embryo development.

摘要

背景

高密度脂蛋白（HDL）似乎是人类卵泡液（FF）中占主导地位的脂蛋白颗粒。HDL 的报道中的抗动脉粥样硬化特性部分归因于胆固醇逆转运。清道夫受体 B 类 I 型（SR-BI）和三磷酸腺苷结合盒 A1 脂质（ABCA1）转运蛋白的发现引发了旨在揭示 HDL 生物发生、重塑和分解代谢途径的研究。SR-BI 和 ABCA1 敲除小鼠以及其他与脂蛋白代谢相关的突变体的产生导致生育力降低或丧失，这使我们假设存在人类肝脏-卵巢 HDL 相关的生育轴。在这里，我们综述了关于 HDL 代谢对哺乳动物生育力和卵母细胞发育的作用的不断发展的文献。

方法

对与讨论的部分主题相关的已发表文章进行了广泛的在线搜索。考虑到有关 HDL 代谢的丰富知识，以及生殖领域的相关知识匮乏，所有相关的英文文章均包含在 Pubmed/Medline 中，且没有特定的出版时间框架。心血管文献被大量引用，是因为它包含了有关 HDL 代谢的丰富知识，而生殖领域的相关知识则相对匮乏。