O'Brien A D, Kapral F A
Infect Immun. 1977 Jun;16(3):812-6. doi: 10.1128/iai.16.3.812-816.1977.
Since Staphylococcus aureus delta toxin previously had been shown to increase the cyclic adenosine 3',5'-monophosphate (cAMP) content of guinea pig ileum, the effect of delta toxin on such cAMP-mediated responses as morphogenesis and steroidogenesis in cultured tissue cells was examined. In contrast to cholera toxin, delta toxin did not cause spindling of Chinese hamster ovary cells. Unlike adrenocorticotropin or cholera toxin, delta toxin was unable to cause rounding of Y-1 adrenal cells or to promote steroid production by the cells. S. aureus alpha toxin and enterotoxin B were also unable to cause rounding of Y-1 adrenal cells. Omission of Ca2+ from the media still allowed for increased steroid production by adrenocorticotropin but not by delta toxin. Delta toxin at concentrations greater than 10 micrograms/ml did cause lysis of both Chinese hamster ovary and Y-1 adrenal cells. These findings suggest that the increase in intestinal cAMP levels caused by delta toxin is mediated through a mechanism different from that initiated by cholera toxin.
由于此前已证明金黄色葡萄球菌δ毒素可增加豚鼠回肠中环磷酸腺苷（cAMP）的含量，因此研究了δ毒素对培养组织细胞中形态发生和类固醇生成等cAMP介导反应的影响。与霍乱毒素不同，δ毒素不会导致中国仓鼠卵巢细胞出现纺锤状。与促肾上腺皮质激素或霍乱毒素不同，δ毒素无法使Y-1肾上腺细胞变圆或促进这些细胞产生类固醇。金黄色葡萄球菌α毒素和肠毒素B也无法使Y-1肾上腺细胞变圆。培养基中去除Ca2+仍能使促肾上腺皮质激素增加类固醇生成，但δ毒素却不能。浓度大于10微克/毫升的δ毒素确实会导致中国仓鼠卵巢细胞和Y-1肾上腺细胞裂解。这些发现表明，δ毒素引起的肠道cAMP水平升高是通过一种不同于霍乱毒素引发的机制介导的。
