Richter H, Wiekhorst F, Schwarz K, Lyer S, Tietze R, Alexiou Ch, Trahms L
Physikalisch-Technische Bundesanstalt, Berlin, Germany.
Phys Med Biol. 2009 Sep 21;54(18):N417-24. doi: 10.1088/0031-9155/54/18/N03. Epub 2009 Aug 21.
In magnetic drug targeting a chemotherapeutic agent is bound to coated magnetic nanoparticles, which are administered to the blood vessel system and subsequently focused by an external applied magnetic field. The optimization of intra-arterial magnetic drug targeting (MDT) requires detailed knowledge about the biodistribution of particles in the artery and the respective surrounding after the application. Here, we demonstrate the potential of magnetorelaxometry for quantifying the distribution of magnetic nanoparticles in the artery. To this end, we present a magnetorelaxometry investigation of a MDT study in an artery model. In particular, the absolute magnetic nanoparticle accumulation along the artery as well as the uptake profile along the region around the MDT-magnet position was quantified.
在磁性药物靶向治疗中，化疗药物与包覆的磁性纳米颗粒结合，这些颗粒被注入血管系统，随后通过外部施加的磁场进行聚焦。动脉内磁性药物靶向治疗（MDT）的优化需要详细了解给药后颗粒在动脉及其周围组织中的生物分布情况。在此，我们展示了磁弛豫测量法在定量动脉中磁性纳米颗粒分布方面的潜力。为此，我们对动脉模型中的MDT研究进行了磁弛豫测量研究。特别是，对沿动脉的绝对磁性纳米颗粒积累以及MDT磁体位置周围区域的摄取情况进行了定量分析。
