感染牛白血病病毒的牛的密度梯度分离外周血白细胞的特性
Properties of density gradient-fractionated peripheral blood leukocytes from cattle infected with bovine leukemia virus.
作者信息
Kenyon S J, Piper C E
出版信息
Infect Immun. 1977 Jun;16(3):898-903. doi: 10.1128/iai.16.3.898-903.1977.
Abstract
Discontinuous bovine serum albumin gradients were used to fractionate peripheral blood leukocytes from bovine leukemia virus (BLV)-free and BLV-infected cows. The release of infectious BLV and spontaneous incorporation of [3H]thymidine were not properties of density gradient-fractionated leukocytes from a BLV-free cow. When leukocytes from BLV-infected cattle were fractionated, B lymphocytes which spontaneously incorporated [3H]thymidine could be separated as a distinct subpopulation from B lymphocytes which replicated infectious BLV. Density gradient fractionation of leukocytes from a cow with lymphosarcoma is also reported. A fall in lymphocyte count at the time of tumor development is attributed to the loss of B lymphocytes which spontaneously incorporate [3H]thymidine.
摘要
采用不连续的牛血清白蛋白梯度法对来自无牛白血病病毒（BLV）和感染BLV的奶牛的外周血白细胞进行分级分离。无BLV奶牛的密度梯度分级白细胞不具有传染性BLV的释放和[3H]胸腺嘧啶核苷的自发掺入特性。当对感染BLV牛的白细胞进行分级分离时，自发掺入[3H]胸腺嘧啶核苷的B淋巴细胞可作为一个独特的亚群与复制传染性BLV的B淋巴细胞分离。本文还报道了对患有淋巴肉瘤奶牛的白细胞进行密度梯度分级分离的情况。肿瘤发生时淋巴细胞计数的下降归因于自发掺入[3H]胸腺嘧啶核苷的B淋巴细胞的丢失。
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本文引用的文献
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