使用抗牛白血病细胞单克隆抗体对具有发生白血病潜力的牛进行筛查。
The screening of cattle with potential for developing leukemia by using monoclonal antibody against bovine leukemia cells.
作者信息
Onuma M, Yasutomi Y, Okada H M, Matsukawa K, Yoshikawa H, Yoshikawa T, Okada K, Takahashi K, Kirisawa R, Kawakami Y
机构信息
Department of Veterinary Microbiology, Rakuno Gakuen University, Ebetsu.
出版信息
Jpn J Cancer Res. 1988 Feb;79(2):275-81. doi: 10.1111/j.1349-7006.1988.tb01587.x.
Tumor cells from cattle with enzootic bovine lymphosarcoma (EBL) have a tumor-associated antigen (TAA) which is distinct from bovine leukemia virus (BLV)-induced antigens. We were able to sacrifice 8 TAA-positive cattle with no clinical signs of EBL and to examine whether or not they had gross or histological tumors. At necropsy, 4 animals had tumors macroscopically. Three animals had no tumors histologically but had initial lesions showing follicular hyperplasia and had the TAA on affected lymph nodes. The remaining one showed medullary hyperplasia in the spleen but there were no findings of tumors. These results suggest that most BLV-infected cattle which are TAA-positive but have no clinical signs of EBL, do have tumors and have a higher potential for developing EBL in the future when compared to BLV-infected but TAA-negative cattle.
患有地方流行性牛淋巴肉瘤（EBL）的牛的肿瘤细胞具有一种肿瘤相关抗原（TAA），该抗原不同于牛白血病病毒（BLV）诱导的抗原。我们能够对8头无EBL临床症状的TAA阳性牛实施安乐死，并检查它们是否有肉眼可见或组织学上的肿瘤。尸检时，4只动物肉眼可见有肿瘤。3只动物在组织学上没有肿瘤，但有显示滤泡增生的初始病变，且在受影响的淋巴结上有TAA。其余1只在脾脏中显示髓样增生，但未发现肿瘤。这些结果表明，大多数TAA阳性但无EBL临床症状的BLV感染牛确实有肿瘤，并且与BLV感染但TAA阴性的牛相比，未来发生EBL的可能性更高。
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