Ingouff Mathieu, Berger Frédéric
Department of Biological Sciences, Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore, 117604, Singapore.
Chromosoma. 2010 Feb;119(1):27-33. doi: 10.1007/s00412-009-0237-1. Epub 2009 Aug 23.
Regulation of chromatin activity by covalent histone modifications has been long recognized. Histones that constitute the nucleosome are encoded by large families of genes and display a strong degree of conservation. However, histone variants exist and it is becoming clear that they play important roles in genome regulation. While most studies of the role of histone3 (H3) variants in transcriptional control comes from animal models, emerging data in plants suggest functional conservation, although plant-specific roles are likely. We review these data and speculate on the biological significance of H3 variants in plants.
共价组蛋白修饰对染色质活性的调节早已为人所知。构成核小体的组蛋白由多个基因家族编码，并表现出高度的保守性。然而，组蛋白变体确实存在，并且越来越清楚的是它们在基因组调控中发挥着重要作用。虽然关于组蛋白H3变体在转录控制中作用的大多数研究来自动物模型，但植物中的新数据表明存在功能保守性，尽管可能存在植物特有的作用。我们回顾了这些数据，并推测了植物中H3变体的生物学意义。
