Shojaie Mohammad, Pourahmad Morteza, Eshraghian Ahad, Izadi Hamid Reza, Naghshvar Farzan
Peymanieh Hospital, Internal Medicine Department, Jahrom University of Medical Sciences, Jahrom, Fars, Iran.
Vasc Health Risk Manag. 2009;5:673-6. doi: 10.2147/vhrm.s6559. Epub 2009 Aug 20.
Premature myocardial infarction with life-threatening complications may become epidemic in some Asian and African countries and especially Iran. Fibrinogen is considered as one of the probable risk factors of myocardial infarction. The aim of our study was to assess fibrinogen levels as an etiology of premature myocardial infarction in young Iranian men.
A case-control study was conducted between May 2005 and May 2007 to investigate the association between serum total fibrinogen level and myocardial infarction in men aged younger than 55 years admitted to the cardiac care units of Peymanieh and Motahari Hospitals affiliated to Jahrom University of Medical Sciences, Iran. The mean age of patients was 45.2 +/- 4 years in patients with premature myocardial infarction and 47.06 +/- 4.5 years in the control group (p = 0.085). There were no statistically significant relationships between the two groups in history of premature myocardial infarction in their first-degree relatives (p = 0.05), cigarette smoking (p = 0.46), diabetes (p = 0.49), or hypertension (p = 1). The mean plasma fibrinogen in patients (354.9 +/- 60 mg/dL) was elevated markedly compared with the control group (329 +/- 73 mg/dL). Hyperfibrinogenemia (>340 mg/dL) was detected in 81.8% of patients and 57.5% of controls (95% confidence interval, odds ratio = 3.3; p = 0.036).
This study introduced fibrinogen as a risk factor for premature coronary artery disease in Iranian men.
伴有危及生命并发症的早发性心肌梗死在一些亚洲和非洲国家，尤其是伊朗，可能会成为一种流行病。纤维蛋白原被认为是心肌梗死的可能危险因素之一。我们研究的目的是评估纤维蛋白原水平作为伊朗年轻男性早发性心肌梗死病因的情况。
2005年5月至2007年5月进行了一项病例对照研究，以调查伊朗贾赫罗姆医科大学附属佩亚梅尼亚医院和莫塔哈里医院心脏监护病房收治的55岁以下男性血清总纤维蛋白原水平与心肌梗死之间的关联。早发性心肌梗死患者的平均年龄为45.2±4岁，对照组为47.06±4.5岁（p = 0.085）。两组在一级亲属早发性心肌梗死病史（p = 0.05）、吸烟（p = 0.46）、糖尿病（p = 0.49）或高血压（p = 1）方面无统计学显著关系。患者的平均血浆纤维蛋白原（354.9±60mg/dL）明显高于对照组（329±73mg/dL）。81.8%的患者和57.5%的对照组检测到高纤维蛋白原血症（>340mg/dL）（95%置信区间，优势比 = 3.3；p = 0.036）。
本研究表明纤维蛋白原是伊朗男性早发性冠状动脉疾病的一个危险因素。
