心肌梗死患者的年龄越小，其亲属中患有早发性动脉粥样硬化病史的人数就越多。
Younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature atherosclerosis.
机构信息
Department of Cardiology, Centre of Postgraduate Medical Education, Grochowski Hospital, Grenadierów 51/59, 04-730, Warsaw, Poland.
出版信息
BMC Cardiovasc Disord. 2020 Sep 11;20(1):410. doi: 10.1186/s12872-020-01677-w.
BACKGROUND
Premature coronary artery disease is one of the most pressing global issues in modern cardiology. The aim of the study was to investigate the role of family history of premature cardiovascular disease (CVD) in patients aged < 50 years with myocardial infarction (MI) compared to that in patients aged ≥50 years with MI and to that in young people without MI (no-MI < 50).
METHODS
The studied group (MI < 50) consisted of 240 patients aged 26-49 years with MI. The control groups consisted of 240 patients (MI ≥ 50) with MI aged 50-92 years and 240 healthy people aged 30-49 years without a history of MI (no-MI < 50).
RESULTS
There were statistically significant differences between the MI < 50 and MI ≥ 50 and no-MI < 50 groups regarding the family history of premature MI/ischaemic stroke and the percentage of patients with ≥2 relatives affected (10.8, 2.9, and 3.7%, respectively; p < 0.0001). There was a statistically significant difference in the patient age at the first MI occurrence among patients without a family history of premature CVD, those with 1 affected relative, and those with ≥2 affected first-degree relatives (56.6, 48.6 and 41.8 years, respectively) as well as those with affected first- and second-degree relatives (56.5, 50.7 and 47.0 years, respectively).
CONCLUSIONS
A younger age of patients with myocardial infarction is associated with a higher number of relatives with a history of premature MI/ischaemic stroke. Thus, the family history of premature atherosclerosis involving not only first- but also second-degree relatives seems to be a valuable factor in CVD risk evaluation in young people.
背景
早发性冠心病是现代心脏病学中最紧迫的全球性问题之一。本研究旨在探讨早发性心血管疾病（CVD）家族史在<50 岁心肌梗死（MI）患者中的作用，与≥50 岁 MI 患者及无 MI（<50 岁）年轻人中的作用进行比较。
方法
研究组（MI<50）包括 240 例年龄为 26-49 岁的 MI 患者。对照组包括 240 例年龄为 50-92 岁的 MI≥50 岁患者和 240 例无 MI（<50 岁）的健康人。
结果
MI<50 与 MI≥50 及无 MI<50 组在早发性 MI/缺血性卒中家族史和≥2 名亲属受累的患者比例方面存在统计学显著差异（分别为 10.8%、2.9%和 3.7%；p<0.0001）。无早发性 CVD 家族史、有 1 名受累亲属和有≥2 名受累一级亲属的患者首次 MI 发病年龄存在统计学显著差异（分别为 56.6、48.6 和 41.8 岁），以及有受累一级和二级亲属的患者（分别为 56.5、50.7 和 47.0 岁）。
结论
心肌梗死患者年龄较轻与有更多早发性 MI/缺血性卒中病史的亲属相关。因此，早发性动脉粥样硬化家族史不仅涉及一级亲属，还涉及二级亲属，似乎是评估年轻人 CVD 风险的一个有价值的因素。
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