Kulkarni Prathit A, Afshar-Kharghan Vahid
Baylor College of Medicine, Houston, Texas, USA;
Biologics. 2008 Dec;2(4):671-85. doi: 10.2147/btt.s2753.
The complement system is an important part of innate immunity; however, as with other parts of the immune system, the complement system can become pathologically activated and create or worsen disease. Anticomplement reagents have been studied for several years, but only recently have they emerged as a viable therapeutic tool. Here, we describe the role of the complement system in a wide array of diseases, as well as the use of anticomplement therapy as treatment for these diseases in animal models and in human clinical trials. Specifically, we will discuss the role of anticomplement therapy in paroxysmal nocturnal hemoglobinuria, glomerulonephritis, and heart disease, including coronary artery disease, myocardial infarction, and coronary revascularization procedures such as percutaneous coronary angioplasty and coronary artery bypass graft surgery.
补体系统是固有免疫的重要组成部分；然而，与免疫系统的其他部分一样，补体系统可能会发生病理性激活，从而引发或加重疾病。抗补体试剂已研究多年，但直到最近才成为一种可行的治疗工具。在此，我们描述补体系统在多种疾病中的作用，以及在动物模型和人体临床试验中使用抗补体疗法治疗这些疾病的情况。具体而言，我们将讨论抗补体疗法在阵发性夜间血红蛋白尿、肾小球肾炎和心脏病（包括冠状动脉疾病、心肌梗死以及经皮冠状动脉腔内血管成形术和冠状动脉旁路移植术等冠状动脉血运重建手术）中的作用。
