[Ultrastructural features of somatostatin-containing neurons of the hypothalamus of rats with protein insufficiency].

The electron microscopic investigation was performed to analyze somatostatin-contained nerve terminals in the median eminence of 21 days old malnourished rats' hypothalamus. In nerve terminals of malnourished animals in compared with controls ones there was found the increased density of granular vesicles (11.62 +/- 0.40 and 8.56 +/- 0.39 in 1 micron2, respectively) and decreased density of electron lucent vesicles with 120-160 nm diameter (1.66 +/- 0.18 and 3.43 +/- 0.26 in 1 micro2, respectively). The revealed increase in density of granular vesicles in axon terminals with positive immunohistochemical reaction to somatostatin in malnourished rats was explained by slow somatostatin release.