在BALB/c背景下，γ干扰素缺陷小鼠感染鼠γ疱疹病毒68会导致急性致死性肺炎，且这种肺炎依赖于特定的病毒基因。
Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes.
作者信息
Lee Katherine S, Cool Carlyne D, van Dyk Linda F
机构信息
Department of Microbiology, University of Colorado Denver, School of Medicine, Aurora, Colorado, USA.
出版信息
J Virol. 2009 Nov;83(21):11397-401. doi: 10.1128/JVI.00989-09. Epub 2009 Aug 26.
Abstract
Gamma interferon (IFN-gamma) is critical for the control of chronic infection with murine gammaherpesvirus 68 (gammaHV68). Current data indicate that IFN-gamma has a lesser role in the control of acute replication of gammaHV68. Here, we show that IFN-gamma-deficient mice on the BALB/c genetic background poorly control acute viral replication and succumb to early death by acute pneumonia. Notably, this acute, lethal pneumonia was dependent not only on the viral dose, but also on specific viral genes including the viral cyclin gene, previously identified to be important in promoting optimal chronic infection and reactivation from latency.
摘要
γ干扰素（IFN-γ）对于控制小鼠γ疱疹病毒68（γHV68）的慢性感染至关重要。目前的数据表明，IFN-γ在控制γHV68的急性复制方面作用较小。在此，我们发现，BALB/c遗传背景下的IFN-γ缺陷小鼠对急性病毒复制的控制不佳，并因急性肺炎过早死亡。值得注意的是，这种急性致死性肺炎不仅取决于病毒剂量，还取决于特定的病毒基因，包括病毒细胞周期蛋白基因，该基因先前已被确定在促进最佳慢性感染和从潜伏状态重新激活方面很重要。
相似文献
1
Murine gammaherpesvirus 68 infection of gamma interferon-deficient mice on a BALB/c background results in acute lethal pneumonia that is dependent on specific viral genes.在BALB/c背景下，γ干扰素缺陷小鼠感染鼠γ疱疹病毒68会导致急性致死性肺炎，且这种肺炎依赖于特定的病毒基因。
J Virol. 2009 Nov;83(21):11397-401. doi: 10.1128/JVI.00989-09. Epub 2009 Aug 26.
2
Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner.γ干扰素以细胞类型特异性方式阻断γ疱疹病毒从潜伏状态重新激活。
J Virol. 2007 Jun;81(11):6134-40. doi: 10.1128/JVI.00108-07. Epub 2007 Mar 14.
3
The murine gammaherpesvirus 68 v-cyclin is a critical regulator of reactivation from latency.鼠γ疱疹病毒68型的v-细胞周期蛋白是潜伏激活的关键调节因子。
J Virol. 2000 Aug;74(16):7451-61. doi: 10.1128/jvi.74.16.7451-7461.2000.
4
Gamma interferon blocks gammaherpesvirus reactivation from latency.γ干扰素可阻止γ疱疹病毒从潜伏状态重新激活。
J Virol. 2006 Jan;80(1):192-200. doi: 10.1128/JVI.80.1.192-200.2006.
5
Virus-encoded microRNAs facilitate gammaherpesvirus latency and pathogenesis in vivo.病毒编码的微小RNA促进γ疱疹病毒在体内的潜伏和发病机制。
mBio. 2014 May 27;5(3):e00981-14. doi: 10.1128/mBio.00981-14.
6
Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins.病毒 cyclins 通过整合不同哺乳动物 cyclins 的功能来介导感染的不同阶段。
PLoS Pathog. 2012 Feb;8(2):e1002496. doi: 10.1371/journal.ppat.1002496. Epub 2012 Feb 2.
7
Alpha/beta interferons regulate murine gammaherpesvirus latent gene expression and reactivation from latency.α/β干扰素调节小鼠γ疱疹病毒的潜伏基因表达及从潜伏状态的重新激活。
J Virol. 2005 Nov;79(22):14149-60. doi: 10.1128/JVI.79.22.14149-14160.2005.
8
Immune control of the number and reactivation phenotype of cells latently infected with a gammaherpesvirus.γ疱疹病毒潜伏感染细胞数量及再激活表型的免疫控制
J Virol. 2002 Jul;76(14):7125-32. doi: 10.1128/jvi.76.14.7125-7132.2002.
9
Mouse strain differences in the chemokine response to acute lung infection with a murine gammaherpesvirus.小鼠品系对鼠γ疱疹病毒急性肺部感染的趋化因子反应差异
Viral Immunol. 2004;17(1):69-77. doi: 10.1089/088282404322875467.
10
LXR Alpha Restricts Gammaherpesvirus Reactivation from Latently Infected Peritoneal Cells.LXR Alpha 限制潜伏感染腹膜细胞中的γ疱疹病毒激活。
J Virol. 2019 Mar 5;93(6). doi: 10.1128/JVI.02071-18. Print 2019 Mar 15.
引用本文的文献
1
Combination of proviral and antiviral roles of B cell-intrinsic STAT1 expression defines parameters of chronic gammaherpesvirus infection.B 细胞内固有 STAT1 表达的前病毒和抗病毒作用的组合定义了慢性γ疱疹病毒感染的参数。
mBio. 2024 Nov 13;15(11):e0159824. doi: 10.1128/mbio.01598-24. Epub 2024 Oct 23.
2
RNF213 modulates γ-herpesvirus infection and reactivation via targeting the viral Replication and Transcription Activator.RNF213 通过靶向病毒复制和转录激活因子调节 γ-疱疹病毒感染和再激活。
Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2218825120. doi: 10.1073/pnas.2218825120. Epub 2023 Mar 14.
3
Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68.征服宿主：从鼠γ疱疹病毒 68 中学到的发病机制决定因素。
Annu Rev Virol. 2021 Sep 29;8(1):349-371. doi: 10.1146/annurev-virology-011921-082615.
4
Proteomics of Bronchoalveolar Lavage Fluid Reveals a Lung Oxidative Stress Response in Murine Herpesvirus-68 Infection.支气管肺泡灌洗液的蛋白质组学研究揭示了小鼠疱疹病毒-68 感染中的肺部氧化应激反应。
Viruses. 2018 Nov 27;10(12):670. doi: 10.3390/v10120670.
5
Host Tumor Suppressor p18 Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.宿主肿瘤抑制因子p18作为鼠γ疱疹病毒68激活和发病机制的强效细胞内源性抑制剂发挥作用。
J Virol. 2018 Feb 26;92(6). doi: 10.1128/JVI.01604-17. Print 2018 Mar 15.
6
ATM supports gammaherpesvirus replication by attenuating type I interferon pathway.共济失调毛细血管扩张症突变蛋白（ATM）通过减弱I型干扰素途径来支持γ疱疹病毒的复制。
Virology. 2017 Oct;510:137-146. doi: 10.1016/j.virol.2017.07.014. Epub 2017 Jul 18.
7
The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo.小鼠γ疱疹病毒 68（MHV-68）的小非编码 RNA（sncRNAs）参与调节体内潜伏到裂解的开关。
Sci Rep. 2016 Aug 26;6:32128. doi: 10.1038/srep32128.
8
A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency.一种γ疱疹病毒非编码RNA对于血源性播散和外周潜伏的建立至关重要。
mSphere. 2016 Apr;1(2). doi: 10.1128/mSphere.00105-15. Epub 2016 Mar 2.
9
Gammaherpesvirus small noncoding RNAs are bifunctional elements that regulate infection and contribute to virulence in vivo.γ疱疹病毒小非编码RNA是双功能元件，可调节感染并在体内促成毒力。
mBio. 2015 Feb 17;6(1):e01670-14. doi: 10.1128/mBio.01670-14.
10
Sustained inflammation and differential expression of interferons type I and III in PVM-infected interferon-gamma (IFNγ) gene-deleted mice.持续性炎症以及I型和III型干扰素在感染痘苗病毒的干扰素-γ（IFNγ）基因敲除小鼠中的差异表达。
Virology. 2014 Nov;468-470:140-149. doi: 10.1016/j.virol.2014.07.039. Epub 2014 Aug 28.
本文引用的文献
1
Murine gammaherpesvirus 68 infection of IFNgamma unresponsive mice: a small animal model for gammaherpesvirus-associated B-cell lymphoproliferative disease.γ干扰素无反应小鼠的鼠γ疱疹病毒68感染：一种γ疱疹病毒相关B细胞淋巴增殖性疾病的小动物模型
Cancer Res. 2009 Jul 1;69(13):5481-9. doi: 10.1158/0008-5472.CAN-09-0291. Epub 2009 Jun 16.
2
Endothelial cells support persistent gammaherpesvirus 68 infection.内皮细胞支持γ疱疹病毒68的持续感染。
PLoS Pathog. 2008 Sep 12;4(9):e1000152. doi: 10.1371/journal.ppat.1000152.
3
Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice.病毒再激活的控制可阻止干扰素-γ受体缺陷小鼠中肺疱疹病毒诱导的纤维化。
Am J Respir Crit Care Med. 2007 Jun 1;175(11):1139-50. doi: 10.1164/rccm.200610-1426OC. Epub 2007 Mar 15.
4
Gamma interferon blocks gammaherpesvirus reactivation from latency in a cell type-specific manner.γ干扰素以细胞类型特异性方式阻断γ疱疹病毒从潜伏状态重新激活。
J Virol. 2007 Jun;81(11):6134-40. doi: 10.1128/JVI.00108-07. Epub 2007 Mar 14.
5
Evidence for CDK-dependent and CDK-independent functions of the murine gammaherpesvirus 68 v-cyclin.小鼠γ-疱疹病毒68型v-细胞周期蛋白的CDK依赖性和非CDK依赖性功能的证据。
J Virol. 2006 Dec;80(24):11946-59. doi: 10.1128/JVI.01722-06. Epub 2006 Sep 27.
6
Gamma interferon blocks gammaherpesvirus reactivation from latency.γ干扰素可阻止γ疱疹病毒从潜伏状态重新激活。
J Virol. 2006 Jan;80(1):192-200. doi: 10.1128/JVI.80.1.192-200.2006.
7
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice.小鼠γ-疱疹病毒68感染与BALBβ2微球蛋白缺陷小鼠的淋巴增殖性疾病和淋巴瘤有关。
J Virol. 2005 Dec;79(23):14668-79. doi: 10.1128/JVI.79.23.14668-14679.2005.
8
A surface groove essential for viral Bcl-2 function during chronic infection in vivo.在体内慢性感染期间病毒Bcl-2功能所必需的表面凹槽。
PLoS Pathog. 2005 Sep;1(1):e10. doi: 10.1371/journal.ppat.0010010. Epub 2005 Sep 30.
9
CD4 T cell control of acute and latent murine gammaherpesvirus infection requires IFNgamma.CD4 T细胞对急性和潜伏性小鼠γ疱疹病毒感染的控制需要γ干扰素。
Virology. 2005 Aug 1;338(2):201-8. doi: 10.1016/j.virol.2005.05.011.
10
Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo.鼠γ疱疹病毒68的bcl-2同源物有助于在体内建立潜伏感染。
J Gen Virol. 2005 Jan;86(Pt 1):31-40. doi: 10.1099/vir.0.80480-0.
Zotero 插件