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本文引用的文献

1

High transmissibility of the modern Beijing Mycobacterium tuberculosis in homeless patients of Japan.现代北京分枝杆菌在日本无家可归者中的高传染性。

Tuberculosis (Edinb). 2009 Jul;89(4):252-5. doi: 10.1016/j.tube.2009.05.007. Epub 2009 Jul 9.

2

Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains.典型的结核分枝杆菌北京菌株规避疫苗诱导的免疫。

Emerg Infect Dis. 2009 Feb;15(2):335-9. doi: 10.3201/eid1502.080795.

3

Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei.台北地区结核分枝杆菌的分子流行病学与进化遗传学

BMC Infect Dis. 2008 Dec 22;8:170. doi: 10.1186/1471-2334-8-170.

4

Genetic diversity of the Mycobacterium tuberculosis Beijing family in East Asia revealed through refined population structure analysis.通过精细的种群结构分析揭示东亚结核分枝杆菌北京家族的遗传多样性

FEMS Microbiol Lett. 2009 Feb;291(1):35-43. doi: 10.1111/j.1574-6968.2008.01431.x. Epub 2008 Nov 24.

5

Population structure analysis of the Mycobacterium tuberculosis Beijing family indicates an association between certain sublineages and multidrug resistance.结核分枝杆菌北京家族的群体结构分析表明，某些亚谱系与多重耐药性之间存在关联。

Antimicrob Agents Chemother. 2008 Oct;52(10):3805-9. doi: 10.1128/AAC.00579-08. Epub 2008 Aug 11.

6

Genetic geography of Mycobacterium tuberculosis Beijing genotype: a multifacet mirror of human history?结核分枝杆菌北京基因型的遗传地理学：人类历史的多面镜子？

Infect Genet Evol. 2008 Dec;8(6):777-85. doi: 10.1016/j.meegid.2008.07.003. Epub 2008 Jul 22.

7

Clinical impact of Mycobacterium tuberculosis W-Beijing genotype strain infection on aged patients in Taiwan.结核分枝杆菌W-北京基因型菌株感染对台湾老年患者的临床影响。

J Clin Microbiol. 2008 Sep;46(9):3127-9. doi: 10.1128/JCM.01132-08. Epub 2008 Jul 2.

8

The clinical consequences of strain diversity in Mycobacterium tuberculosis.结核分枝杆菌菌株多样性的临床后果。

Trans R Soc Trop Med Hyg. 2008 Oct;102(10):955-65. doi: 10.1016/j.trstmh.2008.03.025. Epub 2008 May 29.

9

Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan.台湾地区结核分枝杆菌基因型与不同种族及移民群体的关联

Infect Genet Evol. 2008 May;8(3):323-30. doi: 10.1016/j.meegid.2008.02.003. Epub 2008 Feb 15.

10

Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence.一种低适应性耐药结核分枝杆菌菌株在人类免疫缺陷病毒高流行环境中的传播。

J Clin Microbiol. 2008 Apr;46(4):1514-6. doi: 10.1128/JCM.01938-07. Epub 2008 Feb 13.

过去几十年日本结核分枝杆菌北京株的种群结构动态。

Population structure dynamics of Mycobacterium tuberculosis Beijing strains during past decades in Japan.

机构信息

Department of Microbiology, Kobe Institute of Health, Kobe, Japan.

出版信息

J Clin Microbiol. 2009 Oct;47(10):3340-3. doi: 10.1128/JCM.01061-09. Epub 2009 Aug 26.

DOI:10.1128/JCM.01061-09

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2756919/

Abstract

We used 909 strains to compare the population structures of the Mycobacterium tuberculosis Beijing family between different birth-year cohorts in Japan. The results revealed that the spread of a modern sublineage that has high transmissibility is currently increasing, while the spread of an ancient sublineage, STK, has significantly decreased in younger generations.

摘要

我们使用了 909 株菌株，比较了日本不同出生年份队列中结核分枝杆菌北京家族的种群结构。结果表明，具有高传染性的现代亚谱系的传播正在增加，而古老的 STK 亚谱系的传播在年轻一代中显著减少。