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使用 MDCT 评估小梁骨结构：以高分辨率 pQCT 作为参考标准比较 64 层和 320 层 CT。

Assessment of trabecular bone structure using MDCT: comparison of 64- and 320-slice CT using HR-pQCT as the reference standard.

机构信息

Department of Radiology, Charité Campus Mitte, Universitaetsmedizin, Berlin, Germany.

出版信息

Eur Radiol. 2010 Feb;20(2):458-68. doi: 10.1007/s00330-009-1571-7. Epub 2009 Aug 27.

DOI:10.1007/s00330-009-1571-7
PMID:19711081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2814042/
Abstract

OBJECTIVES

The aim of our study was to perform trabecular bone structure analysis with images from 64- and 320-slice multidetector computed tomography (MDCT) and to compare these with high-resolution peripheral computed tomography (HR-pQCT).

MATERIALS AND METHODS

Twenty human cadaver distal forearm specimens were imaged on a 64- and 320-slice MDCT system at 120 kVp, 200 mA and 135 kVp, 400 mA (in-plane pixel size 234 microm; slice thickness 500 microm). HR-pQCT imaging was performed at an isotropic voxel size of 41 microm. Bone volume fraction (BV/TV), trabecular number (Tb.N), thickness (Tb.Th) and separation (Tb.Sp) were computed.

RESULTS

MDCT-derived BV/TV and Tb.Sp were highly correlated (r = 0.92-0.96, p < 0.0001) with the corresponding HR-pQCT parameters. Tb.Th was the only structure measure that did not yield any significant correlation.

CONCLUSION

The 64- and 320-slice MDCT systems both perform equally well in depicting trabecular bone architecture. However, because of constrained resolutions accurate derivation of trabecular bone measures is limited to only a subset of microarchitectural parameters.

摘要

目的

我们的研究旨在使用 64 层和 320 层多层螺旋 CT（MDCT）的图像进行小梁骨结构分析，并将其与高分辨率外周 CT（HR-pQCT）进行比较。

材料与方法

20 个人体尸检的远侧前臂标本在 120kVp、200mA 和 135kVp、400mA 的 64 层和 320 层 MDCT 系统上进行成像（平面像素大小 234μm；层厚 500μm）。HR-pQCT 成像的各向同性体素大小为 41μm。计算骨体积分数（BV/TV）、小梁数（Tb.N）、厚度（Tb.Th）和分离度（Tb.Sp）。

结果

MDCT 衍生的 BV/TV 和 Tb.Sp 与相应的 HR-pQCT 参数高度相关（r=0.92-0.96，p<0.0001）。Tb.Th 是唯一没有显著相关性的结构测量指标。

结论

64 层和 320 层 MDCT 系统在描绘小梁骨结构方面表现相当。然而，由于分辨率受限，小梁骨测量的准确推导仅限于微观结构参数的一个子集。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/a8586b197b22/330_2009_1571_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/cbb5e3298e10/330_2009_1571_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/611bab23fe80/330_2009_1571_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/4a54cad1050a/330_2009_1571_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/2c8d652e28d9/330_2009_1571_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/a8586b197b22/330_2009_1571_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/cbb5e3298e10/330_2009_1571_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/611bab23fe80/330_2009_1571_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/4a54cad1050a/330_2009_1571_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/2c8d652e28d9/330_2009_1571_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c45f/2814042/a8586b197b22/330_2009_1571_Fig5_HTML.jpg

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