从圆果狗牙花中分离得到的双咔啉胺类生物碱A和B，一种阿朴菲-伊波加双吲哚生物碱和一种阿朴菲-阿朴菲双吲哚生物碱。

Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa.

作者信息

Zaima Kazumasa, Hirata Tomoko, Hosoya Takahiro, Hirasawa Yusuke, Koyama Koichiro, Rahman Abdul, Kusumawati Idha, Zaini Noor Cholies, Shiro Motoo, Morita Hiroshi

机构信息

Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo, Japan.

出版信息

J Nat Prod. 2009 Sep;72(9):1686-90. doi: 10.1021/np900365r.

DOI:10.1021/np900365r

PMID:19711971

Abstract

Two new bisindole alkaloids, biscarpamontamine A (1), possessing an aspidosperma-iboga-type skeleton, and biscarpamontamine B (2), having an aspidosperma-aspidosperma-type skeleton, were isolated from stems of Tabernaemontana sphaerocarpa, and their structures were elucidated on the basis of spectroscopic data analysis. The absolute configuration of biscarpamontamine B (2) was established by comparison of its CD spectrum and with that of vobtusine (3). Biscarpamontamine B (2) showed potent cytotoxicity against various human cancer cell lines.

摘要

从圆果狗牙花（Tabernaemontana sphaerocarpa）的茎中分离出两种新的双吲哚生物碱，具有阿朴菲-伊波加型骨架的双卡帕蒙他明A（1）和具有阿朴菲-阿朴菲型骨架的双卡帕蒙他明B（2），并通过光谱数据分析阐明了它们的结构。通过比较双卡帕蒙他明B（2）的圆二色光谱与沃布廷（3）的圆二色光谱确定了其绝对构型。双卡帕蒙他明B（2）对多种人类癌细胞系显示出强大的细胞毒性。