杰兰蒂宁A - G，来自伞花鸡蛋花的具有细胞毒性的阿朴菲生物碱。

Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa.

作者信息

Lim Kuan-Hon, Hiraku Osamu, Komiyama Kanki, Kam Toh-Seok

机构信息

Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia.

出版信息

J Nat Prod. 2008 Sep;71(9):1591-4. doi: 10.1021/np800435c. Epub 2008 Sep 9.

DOI:10.1021/np800435c

PMID:18778099

Abstract

Seven new indole alkaloids of the Aspidosperma type, jerantinines A-G (1-7), were isolated from a leaf extract of the Malayan Tabernaemontana corymbosa. The structures were established using NMR and MS analysis. Five of the alkaloids isolated and two derivatives (1-5, 8, 9) displayed pronounced in vitro cytotoxicity against human KB cells (IC50 < 1 microg/mL).

摘要

从马来西亚伞房狗牙花的叶提取物中分离出7种新的阿朴菲型吲哚生物碱，即杰兰廷宁A - G（1 - 7）。通过核磁共振（NMR）和质谱（MS）分析确定了其结构。分离得到的5种生物碱和2种衍生物（1 - 5、8、9）对人KB细胞显示出显著的体外细胞毒性（半数抑制浓度IC50 < 1微克/毫升）。