Tabernaesines A-I, Cytotoxic Aspidosperma-Aspidosperma-Type Bisindole Alkaloids from .

Twenty-one aspidosperma-aspidosperma alkaloids, including the new tabernaesines A-J (-), were obtained from . The structures and absolute configurations were elucidated using HRMS and NMR experiments. Compounds - possessed a rare spiro heterocycle moiety between the monomeric units, while compounds and were characterized by an indole ring fused with an (,-diethyl)methyl amino group. Compounds , -, , and exhibited moderate cytotoxic potency against various human cancer cell lines at IC 2.5-9.8 μM.