Renukaswamy Gayathri Mandya, Boardman Simone J, Sebire Neil J, Hartley Benjamin E J
Otolaryngology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom.
Int J Pediatr Otorhinolaryngol. 2009 Nov;73(11):1598-600. doi: 10.1016/j.ijporl.2009.07.025. Epub 2009 Aug 27.
Angiosarcoma is a rare tumour of endothelial cell origin whilst malignant skull base tumours are highly unusual in paediatric patients. This case reports an angiosarcoma involving the clivus and basi-sphenoid region of the skull base, in a 1-year-old boy. This tumour is extremely rare in childhood, particularly in this site. The histological features were consistent with a high-grade haemangioendothelioma, categorised as an angiosarcoma. The characteristics of this rare malignancy and the challenges in its management are discussed. This is the youngest reported patient, to our knowledge, with an angiosarcoma of the skull base.
血管肉瘤是一种罕见的内皮细胞起源肿瘤,而恶性颅底肿瘤在儿科患者中极为罕见。本病例报告了一名1岁男孩,其颅底斜坡和蝶骨基部区域发生了血管肉瘤。这种肿瘤在儿童期极为罕见,尤其是在该部位。组织学特征与高级别血管内皮瘤一致,归类为血管肉瘤。本文讨论了这种罕见恶性肿瘤的特征及其治疗挑战。据我们所知,这是报道的最年轻的颅底血管肉瘤患者。