Yamada Shigeru, Shinoto Makoto, Shigeo Yasuda, Imada Hiroshi, Kato Hirotoshi, Kamada Tadashi, Tsujii Hirohiko
National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Inage-ku, Chiba, Japan.
Gan To Kagaku Ryoho. 2009 Aug;36(8):1263-6.
To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with locally recurrent rectal cancer.
We conducted a phase I / II dose escalation of carbon ion radiotherapy. One hundred twelve patients with 117 sites of locally recurrent cancer receiving carbon ion radiotherapy were analyzed.
None of 112 patients experienced National Cancer Institute-Common Toxicity Criteria grade 3 to 5 acute reactions. The local control rate in patients treated with 67.2 GyE, 70.4 GyE and 73.6 GyE in the present study was 70%, 89% and 97% at 5 years, respectively. The overall survival rates in patients treated with 73.6 GyE were 72% at 3 years and 40% at 5 years.
Carbon ion radiotherapy seems to be a safe and effective modality in the management of locally recurrent rectal cancer, providing good local control and offering a survival advantage without unacceptable morbidity.
评估碳离子放疗对局部复发性直肠癌患者的耐受性和疗效。
我们进行了碳离子放疗的I/II期剂量递增研究。分析了112例接受碳离子放疗的117个局部复发性癌灶患者。
112例患者均未出现美国国立癌症研究所通用毒性标准3至5级急性反应。在本研究中，接受67.2 GyE、70.4 GyE和73.6 GyE治疗的患者5年局部控制率分别为70%、89%和97%。接受73.6 GyE治疗的患者3年总生存率为72%，5年为40%。
碳离子放疗在局部复发性直肠癌的治疗中似乎是一种安全有效的方式，能提供良好的局部控制并带来生存优势，且无不可接受的发病率。
