Modzelewski P, Szamatowicz J, Laudanski T, Moniuszko-Jakoniuk J, Akerlund M
Institute of Obstetrics and Gynecology, Academy of Medicine, Bialystok, Poland.
Int J Gynaecol Obstet. 1990 Jun;32(2):169-73. doi: 10.1016/0020-7292(90)90484-3.
Spontaneous uterine activity and reactivity to oxytocin, naproxen and PGF2 alpha were studied in vitro in 80 rats, which for 2-8 weeks had been exposed to different concentrations and combinations of Pb2+, Zn2+ and Cu2+ in their water supply or had been given clean water for control. In rats given only Pb2+ in concentrations of 1000 and 500 ppm for 6 weeks the uterine activity was significantly increased, whereas in groups given the other ions alone, or Pb2+ for 6 weeks followed by 2 weeks of clean water or Zn2+ or Cu2+ no change was observed. The responses to the oxytocin, naproxen and PGF2 alpha did not differ. These results suggest that contamination with lead ions might be one of the etiological factors involved in conditions with increased uterine activity.
在80只大鼠中对子宫的自发活动以及对催产素、萘普生和前列腺素F2α的反应性进行了体外研究。这些大鼠在2至8周的时间里，其饮用水中含有不同浓度及组合的铅离子、锌离子和铜离子，或者给予它们清洁水作为对照。在饮用浓度为1000 ppm和500 ppm的铅离子6周的大鼠中，子宫活动显著增强，而在单独给予其他离子的组中，或者给予铅离子6周后再给予2周清洁水、锌离子或铜离子的组中，未观察到变化。对催产素、萘普生和前列腺素F2α的反应没有差异。这些结果表明，铅离子污染可能是子宫活动增强情况所涉及的病因之一。
