Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA.
Int J Eat Disord. 2012 May;45(4):492-500. doi: 10.1002/eat.20976. Epub 2012 Jan 23.
This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors.
The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49, SD = 6.12). Participants completed questionnaires that assessed eating problems and experience of trauma in childhood (ages 0-12) and donated cheek cells for 5-HTTLPR and rs25531 genotyping.
Women carrying a lower expressing allele (i.e., L(G) or S) who were exposed to higher levels of childhood trauma reported significantly higher mean numbers of eating problems (gender × genotype × trauma interaction, p = .006).
These results are consistent with findings that the lower expressing alleles of the SLC6A4 promoter are associated with increased sensitivity to the negative impact of childhood stressors on adult behavioral outcomes.
本研究探讨了 5-羟色胺转运体基因（SLC6A4）启动子三等位基因多态性与童年创伤经历对问题进食行为数量的潜在交互作用。
研究样本由 439 名（64.7%为女性）白种人大学生组成（平均年龄=22.49，标准差=6.12）。参与者完成了评估进食问题和童年（0-12 岁）创伤经历的问卷，并捐献了用于 5-HTTLPR 和 rs25531 基因分型的颊细胞。
暴露于更高水平童年创伤的携带表达水平较低等位基因（即 L(G)或 S）的女性报告的进食问题平均数量显著更高（性别×基因型×创伤的交互作用，p=0.006）。
这些结果与以下发现一致，即 SLC6A4 启动子的表达水平较低的等位基因与对童年应激源对成人行为结果的负面影响的敏感性增加有关。
