Smalinskiene Alina, Lesauskaite Vaiva, Zitkevicius Virgilijus, Savickiene Nijole, Savickas Arunas, Ryselis Stanislovas, Sadauskiene Ilona, Ivanov Leonid
Institute of Cardiology, Kaunas University of Medicine, Kaunas, Lithuania.
Ann N Y Acad Sci. 2009 Aug;1171:314-20. doi: 10.1111/j.1749-6632.2009.04678.x.
Cadmium (Cd) is an important industrial pollutant, even though its mechanism of toxicity has not been completely clarified. Cd(2+) is toxic to a wide range of organs and tissues. Liver and kidneys are the primary target organs of cadmium toxicity. Cd(2+) induces apoptosis and causes necrotic cell death in certain pathophysiological situations. Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. has many beneficial features. It supports the organism's stress response, immune system, and endocrine system, including the adrenal glands, spleen, and thymus gland. The aim of our study was to investigate the effects of the Eleutherococcus senticosus (ES) liquid extract on the accumulation of Cd(2+) in liver and on the mitotic and apoptotic activity of liver cells after chronic intoxication by Cd(2+). Experiments were carried out on white laboratory mice. Laboratory mice were given to drink solutions of different Cd(2+) and ES concentrations for 8 weeks. Cd(2+) concentration in mouse liver was detected using atomic absorption spectroscopy. Mitotic and apoptotic activity of liver cells was expressed as an estimated number of mitotic and apoptotic cells in randomly selected reference areas in a histological slide. ES combined with CdCl(2) leads to a significant decrease of cadmium concentration in the blood and liver of experimental mice. ES decreased the cadmium-induced mitotic and apoptotic activity of liver cells.
镉（Cd）是一种重要的工业污染物，尽管其毒性机制尚未完全阐明。Cd(2+) 对多种器官和组织具有毒性。肝脏和肾脏是镉毒性的主要靶器官。在某些病理生理情况下，Cd(2+) 可诱导细胞凋亡并导致坏死性细胞死亡。刺五加（Eleutherococcus senticosus (Rupr. et Maxim.) Maxim.）具有许多有益特性。它支持机体的应激反应、免疫系统和内分泌系统，包括肾上腺、脾脏和胸腺。我们研究的目的是调查刺五加水提取物对慢性 Cd(2+) 中毒后肝脏中 Cd(2+) 积累以及肝细胞有丝分裂和凋亡活性的影响。实验在白色实验小鼠身上进行。给实验小鼠饮用不同 Cd(2+) 和刺五加浓度的溶液，持续 8 周。使用原子吸收光谱法检测小鼠肝脏中的 Cd(2+) 浓度。肝细胞的有丝分裂和凋亡活性通过组织学切片中随机选择的参考区域中有丝分裂和凋亡细胞的估计数量来表示。刺五加与 CdCl₂ 联合使用可导致实验小鼠血液和肝脏中镉浓度显著降低。刺五加降低了镉诱导的肝细胞有丝分裂和凋亡活性。
