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紫锥菊提取物对镉毒性的影响。

Influence of Echinacea purpurea (L.) Moench extract on the toxicity of cadmium.

作者信息

Zitkevicius Virgilijus, Smalinskiene Alina, Lesauskaite Vaiva, Savickiene Nijole, Savickas Arunas, Ryselis Stanislovas, Kregzdyte Rima, Abdrakhmanov Oleg, Sadauskiene Ilona, Ivanov Leonid

机构信息

Department of Pharmaceutical Chemistry and Pharmacognosy, Kaunas University of Medicine, A. Mickeviciaus 9, LT-43307 Kaunas, Lithuania.

出版信息

Ann N Y Acad Sci. 2007 Jan;1095:585-92. doi: 10.1196/annals.1397.063.

Abstract

Echinacea purpurea (L.) Moench (EP) has many beneficial features, especially strengthening the immune system. Cadmium (Cd) is a ubiquitous metal and cumulative poison that may cause liver and kidney damage and the formation of neoplasia. In this article, the changes in organs and metabolism, the accumulation of various levels of Cd in tissues, and the effects of EP liquid extract on Cd-induced changes in mice were investigated. Experiments were carried out on the white laboratory mice. Solution of different Cd and EP concentrations were given to drink and experiments were performed. The concentration of Cd in mice blood, liver, kidneys, heart, spleen, skeletal muscle was determined using an electrothermal graphite furnace atomic absorption spectrophotometer Perkin-Elmer/Zeeman 3030. Long time per os of extract of EP combined with Cd leads to a significant increase of Cd concentration in blood and investigated organs of experiment mice.

摘要

紫锥菊(Echinacea purpurea (L.) Moench,简称EP)具有许多有益特性,尤其是增强免疫系统。镉(Cd)是一种普遍存在的金属和累积性毒物,可能导致肝脏和肾脏损伤以及肿瘤形成。在本文中,研究了小鼠器官和代谢的变化、不同水平的镉在组织中的积累以及紫锥菊液体提取物对镉诱导变化的影响。实验在白色实验小鼠身上进行。给小鼠饮用不同镉和紫锥菊浓度的溶液并开展实验。使用珀金埃尔默/塞曼3030型电热石墨炉原子吸收分光光度计测定小鼠血液、肝脏、肾脏、心脏、脾脏、骨骼肌中的镉浓度。长期经口给予紫锥菊提取物与镉会导致实验小鼠血液和所研究器官中的镉浓度显著增加。

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