新型刚性3,4-二羟基查尔酮对小鼠的抗炎和镇痛活性评价
Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice.
作者信息
Heidari M R, Foroumadi A, Amirabadi A, Samzadeh-Kermani A, Azimzadeh B S, Eskandarizadeh A
机构信息
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutics and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Ann N Y Acad Sci. 2009 Aug;1171:399-406. doi: 10.1111/j.1749-6632.2009.04904.x.
There have been many reports indicating the analgesic and anti-inflammatory effects of 3,4-dihydroxychalcones. We have designed and synthesized a rigid 3,4-dihydroxychalcone (RDHC) as a possible drug effecting inflammation and nociception. The analgesic and anti-inflammatory effects were evaluated by formalin and hot-plate tests, respectively. The results showed that RDHC induced significant antinociceptive and anti-inflammatory effects (P < 0.01). Maximum analgesia (63.7%) was observed at 37.5 mg/kg in the first phase of the formalin test. The effect of RDHC was higher in the chronic phase (inflammation phase) of the formalin test (86.4%, P < 0.01). In addition, a significant analgesia (maximum possible effect; MPE = 30.1%) was observed in the hot plate test 45 min after injection of 37.5 mg/kg RDHC (P < 0.01). As a result of our findings, this new RDHC could be suggested for further pharmacological studies.
已有许多报告指出3,4 - 二羟基查耳酮具有镇痛和抗炎作用。我们设计并合成了一种刚性3,4 - 二羟基查耳酮（RDHC），作为一种可能对炎症和痛觉产生影响的药物。分别通过福尔马林试验和热板试验评估其镇痛和抗炎作用。结果表明，RDHC具有显著的抗伤害感受和抗炎作用（P < 0.01）。在福尔马林试验的第一阶段，37.5 mg/kg剂量时观察到最大镇痛率为63.7%。RDHC在福尔马林试验的慢性期（炎症期）效果更佳（86.4%，P < 0.01）。此外，注射37.5 mg/kg RDHC后45分钟，在热板试验中观察到显著的镇痛效果（最大可能效应；MPE = 30.1%，P < 0.01）。基于我们的研究结果，这种新型RDHC可用于进一步的药理学研究。
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