Laegreid L, Olegård R, Conradi N, Hagberg G, Wahlström J, Abrahamsson L
Department of Paediatrics II, Gothenburg University, Göteborg, Sweden.
Dev Med Child Neurol. 1990 May;32(5):432-41. doi: 10.1111/j.1469-8749.1990.tb16962.x.
This study assessed potential teratogenic properties of benzodiazepine (BZD) intake during early pregnancy. Four neonatal diagnoses of congenital malformations (embryopathy and fetopathy, unspecified; unspecified congenital malformations of the nervous system; cleft palate and cleft lip; congenital malformations of the urinary tract) were selected. The authors' previous clinical experience had shown these diagnoses to be characteristic of infants born to mothers with excessive intake of BZD in early pregnancy. The selected diagnoses were present in 25 of 10,646 liveborn infants (2.3 per 1000) delivered by mothers living in the city of Gothenburg in 1985 and 1986. In 18 of these cases, it was possible to analyse maternal plasma, and eight samples (44 per cent) were found to be BZD-positive. Of 60 controls, two maternal blood samples (3 per cent) were positive for BZD. The difference is highly significant and suggests an association between these congenital malformations and BZD consumed during early gestation.
本研究评估了妊娠早期服用苯二氮䓬类药物（BZD）的潜在致畸特性。选取了四种先天性畸形的新生儿诊断病例（未明确的胚胎病和胎儿病；未明确的神经系统先天性畸形；腭裂和唇裂；泌尿道先天性畸形）。作者之前的临床经验表明，这些诊断是妊娠早期过量服用BZD的母亲所生婴儿的特征。在1985年和1986年居住在哥德堡市的母亲所分娩的10646例活产婴儿中，有25例出现了所选的诊断病例（每1000例中有2.3例）。在其中18例病例中，能够分析母亲的血浆，发现8份样本（44%）的BZD呈阳性。在60名对照者中，有两份母亲血液样本（3%）的BZD呈阳性。差异具有高度显著性，表明这些先天性畸形与妊娠早期摄入的BZD之间存在关联。
