Donham K J, VanDerMaaten M J, Miller J M, Kruse B C, Rubino M J
J Natl Cancer Inst. 1977 Sep;59(3):851-3. doi: 10.1093/jnci/59.3.851.
A seroepidemiologic study was conducted in an attempt to identify antibodies against the bovine leukemia virus (BLV) in people exposed to cattle with lymphosarcoma. Farm families, farm employees, and veterinarians in contact with cow herds having documented cases of lymphosarcoma were tested for precipitating antibodies to the BLV with the agar gel immunodiffusion test. The cattle also were tested serologically. Information was collected form the farm families regarding consumption of unpasteurized milk from their dairy herd. Twenty-one dairy herds with documented cases of lymphosarcoma were identified. A total of 846 cows from these herds wre bled, of which 33% were serologically positive. No positive sera were found in the 45 dairy farmers, family members, and farm employees associated with the herds with lymphosarcoma. Consumption of raw milk was reported by 77% of the farm group. In addition, 83 veterinarians, 30 leukemia patients, and 200 control human sera were tested and found negative for antibodies to the BLV.
开展了一项血清流行病学研究，试图在接触患有淋巴肉瘤的牛的人群中鉴定抗牛白血病病毒（BLV）抗体。对与有记录的淋巴肉瘤病例的牛群接触的农场家庭、农场雇员和兽医进行检测，采用琼脂凝胶免疫扩散试验检测抗BLV的沉淀抗体。这些牛也进行了血清学检测。收集了农场家庭关于其奶牛群未杀菌牛奶消费情况的信息。确定了21个有记录的淋巴肉瘤病例的奶牛群。从这些牛群中共采集了846头牛的血液，其中33%血清学呈阳性。在与患有淋巴肉瘤的牛群相关的45名奶农、家庭成员和农场雇员中未发现阳性血清。77%的农场组报告有饮用生牛奶的情况。此外，对83名兽医、30名白血病患者和200份对照人血清进行检测，发现抗BLV抗体均为阴性。
