Ward M H, Zahm S H, Weisenburger D D, Gridley G, Cantor K P, Saal R C, Blair A
Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892.
Cancer Causes Control. 1994 Sep;5(5):422-32. doi: 10.1007/BF01694756.
Little is known about dietary factors and non-Hodgkin's lymphoma (NHL) risk, although high intakes of animal protein and milk have been associated with NHL in two previous studies. As part of a population-based case-control study of agricultural and other risk factors for NHL in eastern Nebraska (USA), we examined the self- and proxy-reported frequency of consumption of 30 food items by 385 White men and women with NHL and 1,432 controls. Animal protein intake was not associated significantly with the risk of NHL, however, there was a nonsignificantly elevated risk of NHL among men with high milk consumption. Vitamin C, carotene, citrus fruit, and dark green vegetable intakes were inversely significantly related to the risk of NHL for men, but not for women. Among men, the odds ratios for the highest quartiles of both vitamin C and carotene intake were 0.6 (95% confidence intervals = 0.3-1.0). There were no meaningful differences in the associations of nutrient intakes and NHL risk between B- and T-cell lymphomas and histologic types. Risks for low intakes of vitamin C and carotene were greater among men and women with a family history of cancer, particularly a history of lymphatic or hematopoietic cancer among first-degree relatives.
关于饮食因素与非霍奇金淋巴瘤（NHL）风险的了解甚少，尽管在之前的两项研究中，高动物蛋白和牛奶摄入量与NHL有关。作为美国内布拉斯加州东部一项基于人群的NHL农业及其他风险因素病例对照研究的一部分，我们调查了385名患NHL的白种男性和女性以及1432名对照者自行报告和由他人代报的30种食物的食用频率。动物蛋白摄入量与NHL风险无显著关联，然而，高牛奶摄入量的男性患NHL的风险虽未显著升高，但有一定程度增加。维生素C、胡萝卜素、柑橘类水果和深绿色蔬菜的摄入量与男性患NHL的风险呈显著负相关，但与女性无关。在男性中，维生素C和胡萝卜素摄入量最高四分位数的比值比均为0.6（95%置信区间=0.3-1.0）。B细胞淋巴瘤和T细胞淋巴瘤以及组织学类型在营养素摄入量与NHL风险的关联方面没有有意义的差异。有癌症家族史，尤其是一级亲属中有淋巴或造血系统癌症家族史的男性和女性，维生素C和胡萝卜素低摄入量的风险更大。
