Mittal Vikrant, Muralee Sunanda, Tampi Rajesh R
Parkland Health Center, 1103 West Liberty Street, Farmington, MO 63640, USA.
Case Rep Med. 2009;2009:802121. doi: 10.1155/2009/802121. Epub 2009 Aug 19.
Valproic acid and its derivatives are commonly used to treat many psychiatric conditions in the elderly. Hyperammonemia is a less common but important side effect of these drugs. The elderly patient appears highly vulnerable to this side effect of this group of medications. In this paper, we systematically review the published literature for hyperammonemia induced by valproic acid and its derivatives. We describe the three reported cases and review possible treatment strategies for this condition.
丙戊酸及其衍生物常用于治疗老年人的多种精神疾病。高氨血症是这些药物较罕见但重要的副作用。老年患者似乎对这类药物的这种副作用高度敏感。在本文中，我们系统回顾了关于丙戊酸及其衍生物所致高氨血症的已发表文献。我们描述了三例报告病例，并探讨了针对这种情况可能的治疗策略。
