Department of Pathology, Laboratory Medicine Neuropathology, David Geffen School of Medicine, University of California, Los Angeles, Calif 92093-0603 , USA.
Brain Pathol. 2010 Mar;20(2):459-67. doi: 10.1111/j.1750-3639.2009.00322.x. Epub 2009 Jul 16.
Cerebral amyloid angiopathy (CAA) is common in elderly individuals, especially those affected with Alzheimer's disease. Eighteen brains with severe SCAA (SCAA) were compared with 21 brains with mild CAA (MCAA) to investigate whether the presence of SCAA in the brains of demented patients was associated with a higher burden of old microinfarcts than those with MCAA. Immunohistochemistry for CD68 was employed to highlight old microinfarcts in tissue blocks from various brain regions. Old microinfarcts, manually counted by light microscopy, were present in 14 of 18 SCAA brains and in 7 of 21 MCAA brains (P = 0.01, two-tailed Fisher's exact test). The average number of old microinfarcts across geographic regions in each brain ranged from 0 to 1.95 (mean rank 24.94, sum of ranks 449) in the SCAA group, and from 0 to 0.35 (mean rank 15.76, sum of ranks 331) in the MCAA group (P = 0.008, two-tailed Mann-Whitney U-test). Frequent old microinfarcts in demented individuals with severe CAA may contribute a vascular component to the cognitive impairment in these patients.
脑淀粉样血管病（CAA）在老年人中很常见，尤其是那些患有阿尔茨海默病的患者。本研究比较了 18 例严重脑淀粉样血管病（SCAA）脑和 21 例轻度脑淀粉样血管病（MCAA）脑，以探讨痴呆患者脑内 SCAA 的存在是否与陈旧微梗死负担高于 MCAA 相关。采用 CD68 免疫组化来突出显示来自不同脑区的组织块中的陈旧微梗死。在 18 例 SCAA 脑和 21 例 MCAA 脑中有 14 例（P = 0.01，双侧 Fisher 确切检验）和 7 例存在陈旧微梗死（P = 0.01，双侧 Fisher 确切检验）。在 SCAA 组中，每个脑的各个地理区域的陈旧微梗死的平均数量从 0 到 1.95（平均秩 24.94，总秩 449），在 MCAA 组中从 0 到 0.35（平均秩 15.76，总秩 331）（P = 0.008，双侧 Mann-Whitney U 检验）。在严重 CAA 的痴呆患者中频繁出现陈旧微梗死可能为这些患者的认知障碍增加了血管成分。
