Department of Pediatrics, Saint-Vincent-de-Paul-Cochin Hospitals, Assistance Publique Hôpitaux de Paris, and University of Paris Descartes, F-75014 Paris, France.
J Clin Virol. 2009 Nov;46(3):282-5. doi: 10.1016/j.jcv.2009.07.021. Epub 2009 Sep 1.
Group A rotaviruses are the main viral causative agent of acute diarrhea, and cause considerable morbidity in children. G9 rotaviruses have recently emerged all over the world and are thought to give more severe symptoms because of a lack of previous exposure and the absence of maternal antibodies in patients.
To determine the clinical severity of G9 infections compared to G1 infections in hospitalized children.
The prospective study was conducted from 2004 to 2007 in French children under 5 years old hospitalized for acute gastroenteritis. The rotaviruses were detected in stools by ELISA tests and genotyped by RT-PCR on the basis of their outer capsid proteins. The duration of hospitalization, the Vesikari clinical score, and the requirement for intravenous rehydration were compared.
The stools from 370 children were analyzed and 162 stools infected by G1 (n=76) or G9 (n=86) rotaviruses were analyzed. Age and gender distribution were similar in the two groups as was the mean duration of hospitalization (2.7 days). The Vesikari scores were 12.96 and 12.83 in G1P[8] and G9P[8] groups (p=0.417), respectively, in which 55.3 and 53.5% of the children, respectively, were rehydrated with an intravenous line.
No difference in severity was found between G1 and G9 rotavirus infections. Rigorous surveillance to monitor changes in the ecology of rotavirus infections is necessary, as emerging strains are more likely to cause severe gastroenteritis and not respond to current rotavirus vaccines.
A 组轮状病毒是急性腹泻的主要病毒病原体，在儿童中造成相当大的发病率。G9 轮状病毒最近在全球范围内出现，由于患者缺乏先前的暴露和母体抗体，因此被认为会引起更严重的症状。
确定与 G1 感染相比，住院儿童中 G9 感染的临床严重程度。
这项前瞻性研究于 2004 年至 2007 年在法国 5 岁以下因急性肠胃炎住院的儿童中进行。通过 ELISA 试验在粪便中检测轮状病毒，并基于其外壳蛋白通过 RT-PCR 对其进行基因分型。比较住院时间、Vesikari 临床评分和静脉补液的需求。
分析了 370 例儿童的粪便，分析了 162 例感染 G1（n=76）或 G9（n=86）轮状病毒的粪便。两组的年龄和性别分布相似，平均住院时间（2.7 天）也相似。G1P[8]和 G9P[8]组的 Vesikari 评分分别为 12.96 和 12.83（p=0.417），分别有 55.3%和 53.5%的儿童需要静脉补液。
G1 和 G9 轮状病毒感染之间未发现严重程度差异。需要进行严格监测，以监测轮状病毒感染生态的变化，因为新出现的毒株更有可能引起严重的肠胃炎，并且对当前的轮状病毒疫苗没有反应。
