1型脊髓灰质炎病毒的病毒多肽结构与减毒的相关性
Correlation of virus polypeptide structure with attenuation of poliovirus type 1.
作者信息
Milstien J B, Walker J R, Eron L J
出版信息
J Virol. 1977 Sep;23(3):811-5. doi: 10.1128/JVI.23.3.811-815.1977.
Abstract
Several avirulent samples of poliovirus type 1 derived in the process attenuating the neurovirulent Mahoney strain show an altered virus capsid polypeptide, VP-1, on polyacrylamide gel electrophoresis of sodium dodecyl sulfate-disrupted virions.
摘要
在减毒强毒株Mahoney株的过程中获得的几个1型脊髓灰质炎病毒无毒力样本，在十二烷基硫酸钠裂解的病毒粒子的聚丙烯酰胺凝胶电泳中显示出病毒衣壳多肽VP-1发生了改变。
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