Savage Sharon A
Clinical Genetics Branch, Division of Cancer, Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS/7018, Rockville, MD 20892, USA, Tel.: +1 301 496 5785, ,
Per Med. 2008 Nov 1;5(6):589-597. doi: 10.2217/17410541.5.6.589.
Genome-wide association studies of hundreds of thousands of SNPs have led to a deluge of studies of genetic variation in cancer and other common diseases. Large case-control and cohort studies have identified novel SNPs as markers of cancer risk. Genome-wide association study SNP data have also advanced understanding of population-specific genetic variation. While studies of risk profiles, combinations of SNPs that may increase cancer risk, are not yet clinically applicable, future, large-scale studies will make individualized cancer screening and prevention possible.
对数以十万计的单核苷酸多态性（SNP）进行的全基因组关联研究，引发了大量关于癌症及其他常见疾病遗传变异的研究。大型病例对照研究和队列研究已确定了新的SNP作为癌症风险标志物。全基因组关联研究的SNP数据也增进了对人群特异性遗传变异的理解。虽然对风险概况（可能增加癌症风险的SNP组合）的研究尚未在临床上应用，但未来的大规模研究将使个性化癌症筛查和预防成为可能。
