Lundberg Jon O, Weitzberg Eddie
Department of Physiology and Pharmacology, Division of Pharmacology Karolinska Institutet, Stockholm, Sweden.
Arch Pharm Res. 2009 Aug;32(8):1119-26. doi: 10.1007/s12272-009-1803-z. Epub 2009 Aug 29.
The nitrate-nitrite-NO pathway is emerging as a likely regulator of physiological functions in the gastrointestinal tract and in the cardiovascular system. In particular, it might serve as a backup system to ensure NO like bioactivity also in situations when the endogenous L-arginine/NO synthase pathway is dysfunctional. In addition, this alternative pathway can be harnessed therapeutically in prevention and treatment of disease. Finally, there is an intriguing nutritional aspect to this, since the major supply of nitrate and nitrite in our bodies comes from our everyday diet. Here we review recent advances in this exciting area of research.
硝酸盐-亚硝酸盐-一氧化氮途径正逐渐成为胃肠道和心血管系统生理功能的一种可能调节因子。特别是，当内源性L-精氨酸/一氧化氮合酶途径功能失调时，它可能作为一种备用系统，以确保在这种情况下也具有一氧化氮样生物活性。此外，这种替代途径可用于疾病的预防和治疗。最后，这还有一个有趣的营养方面，因为我们体内硝酸盐和亚硝酸盐的主要来源是日常饮食。在此，我们综述了这一令人兴奋的研究领域的最新进展。
