Lee Da Young, Lee Seung Yun, Jo Cheorun, Yoon Yohan, Jeong Jong Youn, Hur Sun Jin
Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Korea.
Department of Agricultural Biotechnology, Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Korea.
J Anim Sci Technol. 2021 Sep;63(5):955-976. doi: 10.5187/jast.2021.e101. Epub 2021 Sep 30.
The aim of this study was to investigate the effects of dietary sodium nitrite and meat on human health. Sodium nitrite in processed meat is known to be one of the main precursors of carcinogens, such as N-nitroso compounds. However, we previously found that processed meat is not the primary source of sodium nitrite; nitrate or the conversion of nitrate in vegetables are contribute to generate more than 70% Sodium nitrite or nitrate containing compounds in body. Although the heavy consumption of meat is likely to cause various diseases, meat intake is not the only cause of colorectal cancer. Our review indicates that sodium nitrite derived from foods and endogenous nitric oxide may exhibit positive effects on human health, such as preventing cardiovascular disease or improving reproductive function. Therefore, further epidemiological studies considering various factors, such as cigarette consumption, alcohol consumption, stress index, salt intake, and genetic factors, are required to reliably elucidate the effects of dietary sodium nitrite and meat on the incidence of diseases, such as colorectal cancer.
本研究的目的是调查膳食亚硝酸钠和肉类对人体健康的影响。加工肉类中的亚硝酸钠是已知的致癌物(如N-亚硝基化合物)的主要前体之一。然而,我们之前发现加工肉类并非亚硝酸钠的主要来源;蔬菜中的硝酸盐或硝酸盐的转化对体内70%以上含亚硝酸钠或硝酸盐的化合物的生成有贡献。尽管大量食用肉类可能会引发各种疾病,但肉类摄入并非结直肠癌的唯一病因。我们的综述表明,食物来源的亚硝酸钠和内源性一氧化氮可能对人体健康有积极影响,如预防心血管疾病或改善生殖功能。因此,需要进一步开展考虑多种因素(如吸烟、饮酒、压力指数、盐摄入量和遗传因素)的流行病学研究,以可靠地阐明膳食亚硝酸钠和肉类对结直肠癌等疾病发病率的影响。